NB110-85524 Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) antibody

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Mouse anti Bovine, Canine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) 1H8


Product Description for Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b)

Mouse anti Bovine, Canine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) 1H8.
Presentation: Purified
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot.

Properties for Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b)

Product Category Primary Antibodies
Quantity 0.2 mg
Synonyms EC, EC=, GSK-3 alpha, GSK-3 beta, GSK3A, GSK3B, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta
Presentation Purified
Reactivity Bov, Can, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh
Applications C, IP, WB
Clonality Monoclonal
Clone 1H8
Host Mouse
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant Xenopus GSK-3beta protein
Application immunohistochemistry , immunoprecipitation , Western Blot
Background Glycogen Synthase Kinase 3beta (GSK-3beta) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3beta on serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3beta is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3beta. The phosphorylated serine binds to the GSK-3beta priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3beta participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3beta is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3beta via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3beta with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3beta inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.
protein G purified
protein G purified
Reacts with human, pig, cow, mouse, rat, canine, hamster, monkey, rabbit, sheep. Not tested in other species.

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