AP51874PU-N GNAS (C-term) antibody

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0.4 ml / €370.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human GNAS

AP51874PU-N

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Product Description for GNAS

Rabbit anti Human GNAS.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Western blot / Immunoblot.

Properties for GNAS

Product Category Primary Antibodies
Quantity 0.4 ml
Presentation Aff - Purified
Reactivity Hu
Applications F, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q5FWY2
Immunogen:
KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of Human GNAS
Property C-term
Add. information Molecular Weight: 44;250 Da
Application

ELISA: 1/1000.
Western Blot: 1/100-1/500. 
Flow Cytometry: 1/10-1/50. 
Immunofluorescence: 1/10-1/50.
Immunohistochemistry on Paraffin Sections: 1/10-1/50.

Background Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
Concentration lot specific
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Protein A column, followed by peptide affinity purification
Buffer System:
PBS containing 0.09% (W/V) Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody recognizes Human GNAS (C-term).

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