AP51874PU-N GNAS (C-term) antibody

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0.4 ml / €370.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human GNAS


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Product Description for GNAS

Rabbit anti Human GNAS.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Western blot / Immunoblot.

Properties for GNAS

Product Category Primary Antibodies
Quantity 0.4 ml
Presentation Aff - Purified
Reactivity Hu
Applications F, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of Human GNAS
Property C-term
Add. information Molecular Weight: 44;250 Da

ELISA: 1/1000.
Western Blot: 1/100-1/500. 
Flow Cytometry: 1/10-1/50. 
Immunofluorescence: 1/10-1/50.
Immunohistochemistry on Paraffin Sections: 1/10-1/50.

Background Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
Concentration lot specific

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Protein A column, followed by peptide affinity purification
Buffer System:
PBS containing 0.09% (W/V) Sodium Azide as preservative
Liquid purified Ig fraction
Aff - Purified
This antibody recognizes Human GNAS (C-term).

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