discontinued

GTX25617 GnRH antibody

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Search for all "GnRH"

0.1 ml / €380.00

Quick Overview

Rabbit anti Mouse GnRH

Product Description for GnRH

Rabbit anti Mouse GnRH.
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence.

Properties for GnRH

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Gonadotropin Releasing Hormone, LH-RH, LHRH, Luteinizing Hormone-Releasing Hormone
Reactivity Ms
Applications C, ICC/IF
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide: EHWSYGL RPG (Human).
Application IF, IHC-Fr
Background Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
Concentration 1 mg/ml
Storage Aliquot and store at -20
Format
Buffer System:
Preservative: 0.05% Sodium Azide; Constituents: PBS
Specificity
Specificity:
Cross-reacts with Human and Mouse. Expected to cross-react with Hamster (90% identity with immunogen), Pig (90% identity with immunogen), Rat (90% identity with immunogen), Rhesus monkey (90% identity with immunogen), Sheep (90% identity with immunogen), Xenopus laevis (90% identity with immunogen) due to sequence homology. Not yet tested in other species.

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