SP4677P GPER / GPR30 (N-term, Extracel. Dom.) antibody

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50 µg / €425.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human GPER / GPR30

Product Description for GPER / GPR30

Rabbit anti Human GPER / GPR30.
Properties: (N-term, Extracel. Dom.)
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Properties for GPER / GPR30

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms CEPR, CMKRL2, Chemoattractant receptor-like 2, DRY12, FEG1, Flow-induced endothelial G-protein coupled receptor 1, G-protein coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, LYGPR, Lymphocyte-derived G-protein coupled receptor
Presentation Aff - Purified
Reactivity Hu
Applications ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q99527
Immunogen:
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human GPR30
GeneID:
2852
Remarks:
Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (88%).
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Property N-term, Extracel. Dom.
Application Immunofluorescence.
Immunohistochemistry on Paraffin Sections: 20 µg/ml.
Western Blot.
Background G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK.
Caution Rat GPR30 is also known as GPR41 and HIA-R.
Concentration 1 mg/ml
Product Citations
Purchased from Acris:
1. Chen ZJ, Wei W, Jiang GM, Liu H, Wei WD, Yang X, et al. Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF-κB signals. Mol Oncol. 2016 Jan 18. pii: S1574-7891(16)00012-0. doi: 10.1016/j.molonc.2016.01.002. PubMed PMID: 26842883
2. Weissenborn, C;Ignatov, T;Nass, N;Kalinski, T;Costa, SD;Zenclussen, AC;Ignatov, A. GPER Promoter Methylation Controls GPER Expression in Breast Cancer Patients. Cancer Invest 2017, 1-8. PubMed PMID: 28118074
3. Liu, Q;Chen, Z;Jiang, G;Zhou, Y;Yang, X;Huang, H;Liu, H;Du, J;Wang, H. Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer.Mol. Cancer 2017, 87, 16, 1. PubMed PMID: 28476123.
Originator or purchased from resellers:
  • Zhu, C;Xiong, W;Wang, M;Yang, J. Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer. Journal of International Medical Research 2017, 1-9. DOI: 10.1177/0300060517717625
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography
Buffer System:
PBS containing 0.09% Sodium Azide
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Gorilla, Monkey, Marmoset (tested or 100% immunogen sequence identity).
Specificity
Specificity:
Reacts with N-terminal extracellular domain of  G Protein-Coupled Receptor GPR30 (family: GPCR, subfamily: Transmembrane Estrogen Receptor).
Gene ID 2852

Accessory Products

Proteins and/or Positive Controls

Proteins for GPER / GPR30 (4 products)

Catalog No. Species Pres. Purity   Source  

GPER / GPR30

GPER / GPR30 Human
  Abnova Taiwan Corp.

GPER / GPR30

GPER / GPR30 Human Purified
  Abnova Taiwan Corp.

GPER / GPR30

GPER / GPR30 Human
  Abnova Taiwan Corp.

GPER / GPR30

GPER / GPR30 Human Purified
  Abnova Taiwan Corp.
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