discontinued

bs-2073R GSK3 alpha/beta pTyr279/216 antibody

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0.1 ml / €250.00

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Rabbit anti Human, Mouse, Rat GSK3 alpha/beta

bs-2073R

Product Description for GSK3 alpha/beta

Rabbit anti Human, Mouse, Rat GSK3 alpha/beta.
Properties: pTyr279/216
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for GSK3 alpha/beta

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Factor A, GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha
Presentation Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Bioss, Inc.

Datasheet Extract

Immunogen
Immunogen:
KLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha/Beta around the phosphorylation site of Tyr279/Tyr216.
Property pTyr279/216
Background Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, alpha and beta, and they show a high degree of amino acid homology. The two isoforms of GSK3 are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor 1 (HSF1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer's disease. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.
Product Citations
Originator or purchased from resellers:
  1. Zhao, Hai-hua, et al. "Involvement of GSK3 and PP2A in ginsenoside Rb1's attenuation of aluminum-induced tau hyperphosphorylation." Behavioural Brain Research (2012).
Storage Store at -20°C for 12 months.
Format
Purification:
Purified by Protein A and peptide affinity chromatography.
Buffer System:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
State:
Purified

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