AM06391SU-N GSK3B antibody

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0.1 ml / €400.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human, Monkey, Mouse, Rat GSK3B 3D10


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  • AM06391SU-N
  • AM06391SU-N
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Product Description for GSK3B

Mouse anti Human, Monkey, Mouse, Rat GSK3B 3D10.
Presentation: Ascites
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for GSK3B

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms GSK-3β, GSK3-beta
Presentation Ascites
Reactivity Hu, Mky, Ms, Rt
Applications E, ICC/IF, P, WB
Clonality Monoclonal
Clone 3D10
Host Mouse
Isotype IgG2a
Molecular weight 46 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Purified recombinant fragment of human GSK3B expressed in E. Coli.
Application Western Blot: 1/500 - 1/2000.
Immunohistochemistry on paraffin sections: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: 1/10000.
Background Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transductioncascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β, S6K, RSK, PKA and PKC), dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta-catenin, axin, CK1 and the APC complex).
General Readings
  1. EMBO J. 1998 Mar 2;17(5):1371-84.
  2. Curr Biol. 2001 Jan 9;11(1):44-9.
  3. Cancer Lett. 2003 Sep 25;199(2):201-8.

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Ascitic fluid containing 0.03% sodium azide.
Species Reactivity
Species reactivity (tested):
Human, Rat, Mouse and Monkey.
This antibody reacts to GSK3B.
Gene ID 2942

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