NBP1-04968 HDAC4/HDAC5/HDAC9 pSer246/259/220 antibody

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0.1 mg / €420.00
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Rabbit anti Human, Mouse HDAC4/HDAC5/HDAC9


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  • NBP1-04968

Product Description for HDAC4/HDAC5/HDAC9

Rabbit anti Human, Mouse HDAC4/HDAC5/HDAC9.
Properties: pSer246/259/220
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for HDAC4/HDAC5/HDAC9

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms HDAC-4, HDAC-5, HDAC-9, Histone Deacetylase
Presentation Aff - Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

The antiserum was produced against synthesized phosphopeptide derived from human HDAC4/HDAC5/HDAC9 around the phosphorylation site of serine 246/259/220 (T-A-Sp-E-P).
Property pSer246/259/220
Add. information Research Areas: DNA Repair, Cancer
Application Western Blot, This antibody is useful for Western Blot1:500-1:1000, Western Blot1:500-1:1000,
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC9 has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. HDAC5 is a member of the class II mammalian histone deacetylase family, which is structurally related to yeast HDA1. Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence.Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions. HDAC4 is a class II histone deacetylase containing 1084 amino acid residues. HDAC4 has been shown to interact with NCoR. HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC 4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.
Concentration 1 mg/ml
General Readings Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16.
Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218.
Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703.
Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Affinity purified
Buffer System:
0.02% Sodium Azide
Affinity purified
Aff - Purified
HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) detects endogenous levels of HDAC4/HDAC5/HDAC9 only when phosphorylated at serine 246/259/220.
Human, Mouse

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