NB120-13494 Heat Shock Protein 90 / HSP90 (alpha + beta) antibody

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Rat anti Bovine, Canine, Chicken, Drosophila, Guinea Pig, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep Heat Shock Protein 90 / HSP90 16F1

Product Description for Heat Shock Protein 90 / HSP90

Rat anti Bovine, Canine, Chicken, Drosophila, Guinea Pig, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep Heat Shock Protein 90 / HSP90 16F1.
Properties: (alpha + beta)
Presentation: Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Paraffin Sections, Western blot / Immunoblot.

Properties for Heat Shock Protein 90 / HSP90

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms HSP-84, HSP-86, HSP-90, HSP84, HSP86, HSP90A, HSP90AA1, HSP90AB1, HSP90B, HSPC1, HSPC2, HSPCA, HSPCB, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Renal carcinoma antigen NY-REN-38
Presentation Purified
Reactivity Bov, Can, Chk, Dros, GP, Hu, Mky, Ms, Por, Rb, Rt, Sh
Applications E, ICC/IF, IP, P, WB
Clonality Monoclonal
Clone 16F1
Host Rat
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Human Hsp90 purified from therapeutic orchiectomy specimens.
Property alpha + beta
Isotype control SM15P, SM15PX
Application ELISA, Immunocytochemistry, immunohistochemistry, immunoprecipitation, Western Blot, This antibody is useful for Immunohistochemistry, Immunoprecipitation, Western Blot and Immunocytochemistry., immunohistochemistry, immunoprecipitation, Western Blot 1 ug/ml, Immunocytochemistry, ELISA
Background The 90 kDa molecular chaperone family comprises several proteins including the 90 kDa heat shock protein, Hsp90 and the 94 kDa glucose-regulated protein, grp94 which are major molecular chaperones of the cytosol and of the endoplasmic reticulum. In mammalian cells there are at least two Hsp90 isoforms, Hsp90α and hsp90β which are encoded by separate genes. The amino acid sequence of human and yeast Hsp90α is 85% and 90% homologous to that of Hsp90β respectively (1). All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions which have been shown to contain independent chaperone sites with different substrate specificity (2,3). These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cell
Concentration 1 mg/ml
General Readings
  1. Nemoto, T. et al (1998) Biochem. J. 330: 989-995.
  2. Scheibel, T., Buchner, J. (1997) in Guidebook to Chaperones, ed. Gething, M.J. (Oxford Univ. Press, Oxford), pp. 147-150
  3. Scheibel, T., et al (1999) J. PNAS 96: 1297-1302.
  4. Scheibel, T. et al (1998) J. Biochem. Pharmacol. 56: 675-682.
  5. Rutherford, S. L. et al (1998) Nature 396: 336-342.
  6. Lai, B-T., et al (1984) Molecular & Cellular Biol. 4: 2802-2810.
  7. Holmberg, C. I., et al (1997) J. Biol. Chem. 272: 6792-6798.
  8. Kondo, T., et al. (2000) J. Biol. Chem. 275: 8872-8879.
  9. Gusarova, V., et al (2001) J Biol Chem 276(27): 24891-24900.
  10. Cwiklinska, H., et al (2003) Int Immunol 15(2): 241-249.
  11. Hayem, G., et al (1999) Ann Rheum Dis 58(5): 291-296.
  12. Ricart, J., et al (1997) Biochem J 324(2): 635-643.
  13. White, R.J., et al (2002) Dig Dis Sci 47(8): 1873-1885.
  14. de Carcer, G.; et al (2001) EMBO J 20(11): 2878-2884.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
0.09% Sodium Azide
protein G purified
This affinity purified identifies purified bovine and human (alpha and beta) Hsp90 and will detect an ~90 kDa protein, corresponding to the apparent molecular mass of Hsp90 on SDS-PAGE immunoblots.
Bovine, Canine, Chicken, Drosophila, Guinea Pig, Hamster, Human, Mouse, Porcine, Primate, Rabbit, Rat, Sheep

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