AM33286PU-S Hepatocyte Specific Antigen (HSA) antibody

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0.1 mg / €320.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Canine, Human Hepatocyte Specific Antigen (HSA) SPM582

Product Description for Hepatocyte Specific Antigen (HSA)

Mouse anti Canine, Human Hepatocyte Specific Antigen (HSA) SPM582.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for Hepatocyte Specific Antigen (HSA)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms HepPar-1, hepatocellular carcinoma marker, hepatocyte marker
Presentation Purified
Reactivity Can, Hu
Applications ICC/IF, P
Clonality Monoclonal
Clone SPM582
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Extract of a formalin-fixed, rejected-allograft of a Human liver.
Application Immunofluorescence: 0.5-1 µg/ml. 
Immunohistochemistry on Formalin-Fixed Paraffin 
Sections: 1-2 µg/ml for 30 minutes at RT. 
Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes.
Recommended Positive Control: Liver or Hepatocellular Carcinoma (HCC).
Background Hepatoblastoma is the most common primary tumor of the liver in children. The use of specific hepatocyte markers and also of alpha Fetoprotein or carcinoembryonic antigen are useful for the identification of normal and malignant fetal hepatocytes.
Concentration 0.2 mg/ml
General Readings
  1. Wennerberg AE, Nalesnik MA, Coleman WB. Hepatocyte paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors. Am J Pathol. 1993 Oct;143(4):1050-4. PubMed PMID: 7692729. (Free PMC Article available)
  2. Ramos-Vara JA, Miller MA. Immunohistochemical characterization of canine intestinal epithelial and mesenchymal tumours with a monoclonal antibody to hepatocyte paraffin 1 (Hep Par 1). Histochem J. 2002 Aug-Sep;34(8-9):397-401. PubMed PMID: 12814187.
  3. Fan Z, van de Rijn M, Montgomery K, Rouse RV. Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections. Mod Pathol. 2003 Feb;16(2):137-44. PubMed PMID: 12591966.
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Protein A/G Chromatography
Buffer System:
10mM PBS
0.05% Sodium Azide
0.05% BSA
Liquid purified IgG fraction from Bioreactor Concentrate
Species Reactivity
Species reactivity (tested):
Human and Dog.
Hepatocyte Specific Antigen, also called Hepatocyte Paraffin 1 or Hep Par 1, localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC’s occur primarily in the stomach, but they are also found in many other organs.
The Hepatocyte Specific Antigen may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of the Hepatocyte Specific Antigen correlates with smaller tumor size and longer patient survival. Occasionally, Hepatocyte Specific Antigen is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
Cellular LocalizationFinely granular cytoplasmic.

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