AM06086SU-N Herpes Virus Type 8 / HHV8 ORF45 antibody

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0.1 ml / €440.00
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Mouse anti Herpes Virus Type 8 / HHV8 2D4A5

AM06086SU-N

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  • AM06086SU-N

Product Description for Herpes Virus Type 8 / HHV8

Mouse anti Herpes Virus Type 8 / HHV8 2D4A5.
Properties: ORF45
Presentation: Ascites
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Herpes Virus Type 8 / HHV8

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms KSHV ORF45
Presentation Ascites
Applications ICC/IF, WB
Clonality Monoclonal
Clone 2D4A5
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q2HR88
Immunogen:
Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
GeneID:
4961474
Property ORF45
Application ELISA: 1/10000. 
Western Blot: 1/500 - 1/2000. 
Immunofluorescence: 1/200 - 1/1000. 
Immunohistochemistry: 1/200 - 1/1000.
Background Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
General Readings
  1. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994 Dec 16;266(5192):1865-9. PubMed PMID: 7997879.
  2. Zhu FX, King SM, Smith EJ, Levy DE, Yuan Y. A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5573-8. Epub 2002 Apr 9. PubMed PMID: 11943871. (Free PMC Article available, 6 images available)
  3. Zhu FX. et al. J Virol. 2003. April (77): 4221-4230.
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Preservatives:
0.03% Sodium Azide
State:
Ascitic fluid
Ascites
Specificity
Specificity:
This antibody recognizes KSHV ORF45
Gene ID 4961474

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