bs-12384R HES3 antibody

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0.1 ml / €240.00

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Rabbit anti Human, Mouse, Rat HES3


Product Description for HES3

Rabbit anti Human, Mouse, Rat HES3.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for HES3

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Class B basic helix loop helix protein 43, Hairy and enhancer of split 3, Transcription factor HES 3, bHLHb43
Presentation Purified
Reactivity Hu, Ms, Rt
Applications P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Bioss, Inc.

Datasheet Extract

Swiss Prot Num:
KLH conjugated synthetic peptide derived from human HES3.
Application IHC-P(1:100-500)
Background The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
Storage Store at -20°C for 12 months.
Purified by Protein A.
Buffer System:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.

Accessory Products

Proteins and/or Positive Controls

Proteins for HES3 (1 products)

Catalog No. Species Pres. Purity   Source  

Hairy and enhancer of split 3 (Drosophila) (HES3)

Hairy and enhancer of split 3 (Drosophila) (HES3) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
  OriGene Technologies, Inc.

Positive controls for HES3 (1 products)

Catalog No. Species Pres. Purity   Source  

HES3 overexpression lysate

HES3 overexpression lysate
  OriGene Technologies, Inc.
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