DM069-05 HLA Class II DP, DR, DQ antibody

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Mouse anti Human HLA Class II DP, DR, DQ CR3/43


Product Description for HLA Class II DP, DR, DQ

Mouse anti Human HLA Class II DP, DR, DQ CR3/43.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for HLA Class II DP, DR, DQ

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms DQ, DR, HLA class II histocompatibility antigen DP, HLA-DP, HLA-DQ, HLA-DR, MHC class II antigen DP
Presentation Supernatant
Reactivity Hu
Applications P
Clonality Monoclonal
Clone CR3/43
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Tonsil cells.
Application Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use a dilution of 1/25-1/50 in an ABC method (30 minutes at room temperature).
Positive Control: Tonsil.
Background The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II.
General Readings
  1. Smith et al. J Clin Pathol 40: 34, 1987.
  2. Stein et al. Adv Cancer Res 42: 67, 1984.
  3. Zaloudik et al. J Clin Pathol 41: 1078, 1984.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Tissue Culture Supernatant containing Sodium Azide as preservative.
This antibody reacts with the beta chain of all products of the gene subregions DP, DQ, and DR.
It stains B cells, interdigitating reticulum cells, Langerhan's cells and many macrophages. The antibody does not react with normal T cell and polymorphs but stains activated T cells.
Cellular Localization: Cell membrane.

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