DM069 HLA Class II DP, DR, DQ antibody

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1 ml / €380.00
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Mouse anti Human HLA Class II DP, DR, DQ CR3/43

DM069

Product Description for HLA Class II DP, DR, DQ

Mouse anti Human HLA Class II DP, DR, DQ CR3/43.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for HLA Class II DP, DR, DQ

Product Category Primary Antibodies
Quantity 1 ml
Synonyms DQ, DR, HLA class II histocompatibility antigen DP, HLA-DP, HLA-DQ, HLA-DR, MHC class II antigen DP
Presentation Supernatant
Reactivity Hu
Applications P
Clonality Monoclonal
Clone CR3/43
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Tonsil cells.
Application Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use a dilution of 1/25-1/50 in an ABC method (30 minutes at room temperature).
Positive Control: Tonsil.
Background The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II.
General Readings
  1. Smith et al. J Clin Pathol 40: 34, 1987.
  2. Stein et al. Adv Cancer Res 42: 67, 1984.
  3. Zaloudik et al. J Clin Pathol 41: 1078, 1984.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
State:
Tissue Culture Supernatant containing Sodium Azide as preservative.
Supernatant
Specificity
Specificity:
This antibody reacts with the beta chain of all products of the gene subregions DP, DQ, and DR.
It stains B cells, interdigitating reticulum cells, Langerhan's cells and many macrophages. The antibody does not react with normal T cell and polymorphs but stains activated T cells.
Cellular Localization: Cell membrane.
Species:
Human.

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