discontinued

NB120-17076 HLA Class II DP, DR, DQ antibody

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Mouse anti Human HLA Class II DP, DR, DQ CR3/43

NB120-17076

Product Description for HLA Class II DP, DR, DQ

Mouse anti Human HLA Class II DP, DR, DQ CR3/43.
Product is tested for Frozen Sections, Paraffin Sections.

Properties for HLA Class II DP, DR, DQ

Product Category Primary Antibodies
Quantity 6 ml
Synonyms DQ, DR, HLA class II histocompatibility antigen DP, HLA-DP, HLA-DQ, HLA-DR, MHC class II antigen DP
Reactivity Hu
Applications C, P
Clonality Monoclonal
Clone CR3/43
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
BALB/C mice were injected with membrane rich fraction of human breast carcinoma.
Add. information Research Areas: Lipid and Metabolism, Immunology
Application Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, IHC-P: Prediluted, ready to use for 30 minutes at room temperature. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.IHC-Fr (acetone fixed): Prediluted, ready to use for 30 minutes at room temperature.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user., Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin,
Background The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II. This antibody stains B cells, interdigitating reticulum cells, Langerhan's cells and many macrophages. This antibody does not react with normal T cell and polymorphs but stains activated T cells.
General Readings General / background references:Stein H et al. Immunohistological analysis of human lymphoma: correlation of histological and immunological categories. Adv Cancer Res 42:67-147 (1984). PubMed PMID: 6395656
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Tissue culture supernatant
Buffer System:
Sodium Azide
Purity:
Tissue culture supernatant
Specificity
Specificity:
This antibody reacts with the beta chain of all products of the gene subregions DP, DQ, and DR. It stains B cells, interdigitating reticulum cells, Langerhan's cells and many macrophages. This antibody does not react with normal T cell and polymorphs but stains activated T cells.
Species:
Human

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