NB120-17101 HLA Class II DP, DR, DQ antibody

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1 ml / €420.00

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Mouse anti Human HLA Class II DP, DR, DQ CR3/43


Product Description for HLA Class II DP, DR, DQ

Mouse anti Human HLA Class II DP, DR, DQ CR3/43.
Product is tested for Paraffin Sections.

Properties for HLA Class II DP, DR, DQ

Product Category Primary Antibodies
Quantity 1 ml
Synonyms DQ, DR, HLA class II histocompatibility antigen DP, HLA-DP, HLA-DQ, HLA-DR, MHC class II antigen DP
Reactivity Hu
Applications P
Clonality Monoclonal
Clone CR3/43
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Unfortunately, this information is considered to be commercially sensitive
Add. information Research Areas: Lipid and Metabolism, Immunology
Application Immunohistochemistry-Paraffin, IHC-P: 1/25 - 1/50, in an ABC method.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user., Immunohistochemistry-Paraffin
Background The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II.
General Readings General / background references:Zaloudik J et al. DNA content and MHC class II antigen expression in malignant melanoma: clinical course. J Clin Pathol 41:1078-84 (1988). PubMed PMID: 3192729
Smith ME et al. Major histocompatibility complex class II antigen expression in B and T cell non-Hodgkin's lymphoma. J Clin Pathol 40:34-41 (1987). PubMed PMID: 3546388
Stein H et al. Immunohistological analysis of human lymphoma: correlation of histological and immunological categories. Adv Cancer Res 42:67-147 (1984). PubMed PMID: 6395656
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tissue culture supernatant
Buffer System:
Sodium Azide
Tissue culture supernatant
This antibody reacts with the beta chain of all products of the gene sub regions DP, DQ, and DR. It stains B cells, interdigitating reticulum cells, Langerhans cells and many macrophages. This does not react with normal T cell and polymorphs but stains activated T cells.

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