SM1225F HLA Class II DP, DR, DQ antibody

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0.1 mg / €400.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human HLA Class II DP, DR, DQ WR18

SM1225F

Product Description for HLA Class II DP, DR, DQ

Mouse anti Human HLA Class II DP, DR, DQ WR18.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for HLA Class II DP, DR, DQ

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms DQ, DR, HLA class II histocompatibility antigen DP, MHC class II antigen DP
Presentation FITC
Reactivity Hu
Applications F
Clonality Monoclonal
Clone WR18
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human HLA Class II.
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS.0 myeloma cell line.
Application Flow Cytometry: Use 10 µl of Neat-1/10 diluted antibody to label 10e6 cells or 100 µl whole blood.
Background The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II.
The antigen is expressed by B lymphocytes, monocytes and activated T lymphocytes.
Concentration 0.1 mg/ml
General Readings
  1. Moore, K. et al. (1987) J. Pathol. 152: 13.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Label:
Fluorescein Isothiocyanate Isomer 1
FITC
Purification:
Affinity Chromatography on Protein G.
Buffer System:
PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilzer.
State:
Liquid purified IgG fraction.
Specificity
Specificity:
This antibody recognises a common determinant on the beta chain of Human MHC Class II, and stains cells expressing HLA-DR, DP and DQ.
Species:
Human.

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