SM1225R HLA Class II DP, DR, DQ antibody

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100 Tests / €490.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human HLA Class II DP, DR, DQ WR18


Product Description for HLA Class II DP, DR, DQ

Mouse anti Human HLA Class II DP, DR, DQ WR18.
Presentation: PE
Product is tested for Flow Cytometry.

Properties for HLA Class II DP, DR, DQ

Product Category Primary Antibodies
Quantity 100 Tests
Synonyms DQ, DR, HLA class II histocompatibility antigen DP, MHC class II antigen DP
Presentation PE
Reactivity Hu
Applications F
Clonality Monoclonal
Clone WR18
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Human HLA Class II (DP, DQ, DR).
Spleen cells from an immunised BALB/c mice were fused with cells of the mouse NS0 mouse myeloma cell line.
Application Flow Cytometry: Use 10 µl of neat antibody to label 106 cells or 100 µl whole blood.
Background The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class II proteins encoded by the HLA which are HLA DP, HLA DQ and HLA DR.
General Readings
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  2. Kissner TL, Ruthel G, Alam S, Ulrich RG, Fernandez S, Saikh KU. Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules. PLoS One. 2011 Jan 20;6(1):e15985. doi: 10.1371/journal.pone.0015985. PubMed PMID: 21283748. (Free PMC Article available, 6 images available)
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  5. Litzinger MT, Foon KA, Sabzevari H, Tsang KY, Schlom J, Palena C. Chronic lymphocytic leukemia (CLL) cells genetically modified to express B7-1, ICAM-1, and LFA-3 confer APC capacity to T cells from CLL patients. Cancer Immunol Immunother. 2009 Jun;58(6):955-65. doi: 10.1007/s00262-008-0611-5. Epub 2008 Nov 14. PubMed PMID: 19009294. (Free PMC Article available, 4 images available)
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  7. Sabbah S, Jagne YJ, Zuo J, de Silva T, Ahasan MM, Brander C, et al. T-cell immunity to Kaposi sarcoma-associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells. Blood. 2012 Mar 1;119(9):2083-92. doi: 10.1182/blood-2011-07-366476. Epub 2012 Jan 10. PubMed PMID: 22234686.
  8. John J, Ismail M, Riley C, Askham J, Morgan R, Melcher A, et al. Differential effects of Paclitaxel on dendritic cell function. BMC Immunol. 2010 Mar 19;11:14. doi: 10.1186/1471-2172-11-14. PubMed PMID: 20302610. (Free PMC Article available, 7 images available)
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  10. Silk KM, Leishman AJ, Nishimoto KP, Reddy A, Fairchild PJ. Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype. J Biomed Biotechnol. 2012;2012:172420. doi: 10.1155/2012/172420. Epub 2012 Feb 7. PubMed PMID: 22505805. (Free PMC Article available, 5 images available)
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  12. Silk KM, Silk JD, Ichiryu N, Davies TJ, Nolan KF, Leishman AJ, et al. Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther. 2012 Oct;19(10):1035-40. doi: 10.1038/gt.2011.177. Epub 2011 Nov 10. PubMed PMID: 22071967.
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Storage Prior to and following reconstitution store the antibody at 2-8°C.
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
R. Phycoerythrin (RPE)
Affinity Chromatography on Protein G
Buffer System:
PBS, pH 7.4 containing 0.09% Sodium Azide and 0.1% Bovine Serum Albumin
0.09% Sodium Azide
0.1% BSA
Lyophilized purified IgG fraction
Restore with 1 ml distilled water
This antibody recognizes a monomorphic determinant common to DP, DQ and DR beta chains, which are expressed by antigen presenting cells, B cells, monocytes and activated T lymphocytes.

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