AM26708PU-N HLA Class II DR antibody

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0.1 mg / €220.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Canine, Human, Primate HLA Class II DR L243

AM26708PU-N

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  • AM26708PU-N

Product Description for HLA Class II DR

Mouse anti Canine, Human, Primate HLA Class II DR L243.
Presentation: Purified
Product is tested for Functional assay, Immunocytochemistry/Immunofluorescence, Frozen Sections, Paraffin Sections, Western blot / Immunoblot, Immunoprecipitation, Flow Cytometry.

Properties for HLA Class II DR

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms HLA class II histocompatibility antigen DR, HLA-DR, MHC class II antigen DR
Presentation Purified
Reactivity Can, Hu, Prim
Applications C, F, FN, ICC/IF, IP, P, WB
Clonality Monoclonal
Clone L243
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human B lymphocytes
Isotype control AM03096PU-N
Application Flow Cytometry.
Immunoprecipitation.
Western blot.
Immunohistochemistry on Paraffin Sections.
Immunohistochemistry on Frozen Sections.
Immunocytochemistry.
Functional Application: blocking.
Background HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system. It is expressed on antigen-presenting cells (dendritic cells, B lymphocytes, monocytes, macrophages).
Concentration 1.0 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Coral S, Pucillo C, Leonardi A, Fonsatti E, Altomonte M, Maio M. Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation. Cell Growth Differ. 1997 May;8(5):581-8. PubMed PMID: 9149909.
  2. Cantin R, Martin G, Tremblay MJ. A novel virus capture assay reveals a differential acquisition of host HLA-DR by clinical isolates of human immunodeficiency virus type 1 expanded in primary human cells depending on the nature of producing cells and the donor source. J Gen Virol. 2001 Dec;82(Pt 12):2979-87. PubMed PMID: 11714974.
  3. Muczynski KA, Ekle DM, Coder DM, Anderson SK. Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression. J Am Soc Nephrol. 2003 May;14(5):1336-48. PubMed PMID: 12707403.
  4. Bouillon M, El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W. Lipid raft-dependent and -independent signaling through HLA-DR molecules. J Biol Chem. 2003 Feb 28;278(9):7099-107. Epub 2002 Dec 22. PubMed PMID: 12499388.
  5. Swiatek-de Lange M, Rist W, Stahl HF, Weith A, Lenter MC. Comment on "MHC class II expression identifies functionally distinct human regulatory T cells". J Immunol. 2008 Mar 15;180(6):3625; author reply 3626. PubMed PMID: 18322165.
  6. De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, et al. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3491-6. doi: 10.1073/pnas.0708874105. Epub 2008 Feb 27. PubMed PMID: 18305173. (Free PMC Article available, 6 images available)
  7. Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, et al. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest. 2009 Aug;119(8):2143-59. doi: 10.1172/JCI37884. Epub 2009 Jul 20. PubMed PMID: 19620786. (Free PMC Article available, 10 images available)
  8. Kalka-Moll WM, Tzianabos AO, Bryant PW, Niemeyer M, Ploegh HL, Kasper DL. Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J Immunol. 2002 Dec 1;169(11):6149-53. PubMed PMID: 12444118.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography on Protein A
Buffer System:
PBS, pH~7.4
Preservatives:
15 mM Sodium Azide
State:
Liquid purified IgG fraction (> 95% by SDS-PAGE)
Purified
Species Reactivity
Species reactivity (tested):
Human, Non-Human Primates, Canine (Dog)
Specificity
Specificity:
This antibody recognizes specifically HLA-DR molecules, both peptide-loaded and empty.

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