AM32426FC-N HLA Class II DR antibody

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1ml (100T) / €270.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human HLA Class II DR B-C10

Product Description for HLA Class II DR

Mouse anti Human HLA Class II DR B-C10.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for HLA Class II DR

Product Category Primary Antibodies
Quantity 1ml (100T)
Synonyms HLA class II histocompatibility antigen DR, HLA-DR, MHC class II antigen DR
Presentation FITC
Reactivity Hu
Applications F
Clonality Monoclonal
Clone B-C10
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

RPMI 8866 and DAUDI cell lines.
Myeloma X63/AG.8653 x Balb/c spleen cells.
Isotype control SM12F
Application Flow Cytometry: Use 10 µl to label 106 cells or 100 µl of whole blood.
Background Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II alpha/beta dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Ion Exchange Chromatography
Buffer System:
0.09% Sodium Azide
5% BSA
Liquid purified IgG fraction
Species Reactivity
Species reactivity (tested):
This Monoclonal antibody recognises the HLA Class II (DR) membrane.

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