AM32426FC-N HLA Class II DR antibody

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Search for all "HLA Class II DR"

1ml (100T) / €270.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human HLA Class II DR B-C10

Product Description for HLA Class II DR

Mouse anti Human HLA Class II DR B-C10.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for HLA Class II DR

Product Category Primary Antibodies
Quantity 1ml (100T)
Synonyms HLA class II histocompatibility antigen DR, HLA-DR, MHC class II antigen DR
Presentation FITC
Reactivity Hu
Applications F
Clonality Monoclonal
Clone B-C10
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
RPMI 8866 and DAUDI cell lines.
Myeloma X63/AG.8653 x Balb/c spleen cells.
Application Flow Cytometry: Use 10 µl to label 106 cells or 100 µl of whole blood.
Background Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II alpha/beta dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Label:
FITC
Purification:
Ion Exchange Chromatography
Buffer System:
PBS
Preservatives:
0.09% Sodium Azide
Stabilizers:
5% BSA
State:
Liquid purified IgG fraction
Purified
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
This Monoclonal antibody recognises the HLA Class II (DR) membrane.

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