discontinued

NBP1-33525 HLA class II DR beta 1 / HLA-DRB1 antibody

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Rabbit anti Human HLA class II DR beta 1 / HLA-DRB1

Product Description for HLA class II DR beta 1 / HLA-DRB1

Rabbit anti Human HLA class II DR beta 1 / HLA-DRB1.
Product is tested for Western blot / Immunoblot.

Properties for HLA class II DR beta 1 / HLA-DRB1

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms DR-1, DR1, DRB1-1 beta chain, HLA class II histocompatibility antigen, MHC class II antigen DRB1
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P04229
Immunogen:
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 56 and 260 of Human HLA-DRB1,
Add. information ,
Application Western blot. The usefulness of this product in other applications has not been determined., Western Blot 1:500-1:3000.
Background HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Concentration 0.43 mg/ml
Storage Store at -20C. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7).
Specificity
Specificity:
Membrane
Species:
Human

Accessory Products

Proteins and/or Positive Controls

Proteins for HLA class II DR beta 1 / HLA-DRB1 (2 products)

Catalog No. Species Pres. Purity   Source  

HLA class II DR beta 1 / HLA-DRB1 (30-227, His-tag)

HLA class II DR beta 1 / HLA-DRB1 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

HLA class II DR beta 1 / HLA-DRB1 (30-227, His-tag)

HLA class II DR beta 1 / HLA-DRB1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH
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