NB100-1905 HLA-DQ antibody

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Mouse anti Human, Porcine HLA-DQ SPV-L3


Product Description for HLA-DQ

Mouse anti Human, Porcine HLA-DQ SPV-L3.
Presentation: Ig Fraction
Product is tested for Paraffin Sections.

Properties for HLA-DQ

Product Category Primary Antibodies
Quantity 1 ml
Presentation Ig Fraction
Reactivity Hu, Por
Applications P
Clonality Monoclonal
Clone SPV-L3
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Cells of T4+ CTL clone HG-38.
Add. information Research Areas: Immunology
Application flow cytometry / FACS analysis, immunofluorescence, immunohistochemistry, This antibody can be used in FACS, Immunohistochemistry, and Immunofluorescence. Not tested in other applications. *Optimal dilutions should be determined by the end user., flow cytometry / FACS analysis 1:150-1:300, immunohistochemistry , immunofluorescence
Background MHC class II antigens are transmembrane glycoproteins of non-covalently linked alpha (33-35kDa) and beta (27-30kDa) chains. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. Differential expression of MHC class II antigens on fetal and adult lymphocytes, malignant B cells appears to reflect the stage of cell differentiation which may be useful in the study of lymphoproliferative disorders.
General Readings
  1. Cunningham AC, Milne DS, Wilkes J, Dark JH, Tetley TD, Kirby JA. Constitutive expression of MHC and adhesion molecules by alveolar epithelial cells (type II pneumocytes) isolated from human lung and comparison with immunocytochemical findings. J Cell Sci. 1994 Feb;107 ( Pt 2):443-9. PubMed PMID: 8207072.
  2. Baudouin C, Fredj-Reygrobellet D, Brignole F, Lapalus P, Gastaud P. MHC class II antigen expression by ocular cells in proliferative diabetic retinopathy. Fundam Clin Pharmacol. 1993;7(9):523-30. PubMed PMID: 8314197.
  3. Dimal P; Wilders-Truschnig M; Mooij P; Leb G; Eber O; Langsteger W; Hebenstreit J; Beham A; Stiegler C; Dohr G; et al. Expression of various MHC class II molecules and of intracellular adhesion molecule-1 (ICAM-1) on focal clusters of dendritic cells in iodine deficiency goitres. Clinical and Experimental Immunology, 993, 92(3):397-403.
  4. Mcdonagh AJ, Snowden JA, Stierle C, Elliott K, Messenger AG. HLA and ICAM-1 expression in alopecia areata in vivo and in vitro: the role of cytokines. Br J Dermatol. 1993 Sep;129(3):250-6. PubMed PMID: 7506926.
  5. Suzumura Y, Ohashi M. Immunoelectron localization of HLA-DR, HLA-DP, and HLA-DQ antigens on the microvasculature in normal skin. J Am Acad Dermatol. 1993 Aug;29(2 Pt 1):202-5. PubMed PMID: 8335739.
  6. Thrane PS, Halstensen TS, Haanaes HR, Brandtzaeg P. Increased epithelial expression of HLA-DQ and HLA-DP molecules in salivary glands from patients with Sjögren's syndrome compared with obstructive sialadenitis. Clin Exp Immunol. 1993 May;92(2):256-62. PubMed PMID: 8485911. (Free PMC Article available)
  7. Branchet MC, Boisnic S, Blétry O, Robert L, Charron D, Francès C. Expression of HLA class II antigens on skin fibroblasts in scleroderma. Br J Dermatol. 1992 May;126(5):431-5. PubMed PMID: 1610682.
  8. Cifuentes-Diaz C; Delaporte C; Dautreaux B; Charron D; Fardeau M. Class II MHC antigens in normal human skeletal muscle. Muscle and Nerve, 1992, 15(3):295-302.
  9. Edelstam GA, Lundkvist OE, Klareskog L, Karlsson-Parra A. Cyclic variation of major histocompatibility complex class II antigen expression in the human fallopian tube epithelium. Fertil Steril. 1992 Jun;57(6):1225-9. PubMed PMID: 1376284.
  10. Venning VA, Dean D, Wojnarowska F. Absence of expression of class II major histocompatibility complex determinants on keratinocytes in bullous pemphigoid. Br J Dermatol. 1992 May;126(5):463-7. PubMed PMID: 1610686.
  11. Helbig H, Kittredge KL, Palestine AG, Coca-Prados M, Nussenblatt RB. Gamma-interferon induces differential expression of HLA-DR, -DP and -DQ in human ciliary epithelial cells. Graefes Arch Clin Exp Ophthalmol. 1991;229(2):191-4. PubMed PMID: 1904385.
  12. Thrane PS, Halstensen TS, Rognum TO, Brandtzaeg P. Expression of HLA class I and II (DR, DP and DQ) determinants in fetal and postnatal salivary glands. Scand J Immunol. 1991 Nov;34(5):539-48. PubMed PMID: 1835125.
  13. Hubscher SG, Adams DH, Elias E. Changes in the expression of major histocompatibility complex class II antigens in liver allograft rejection. J Pathol. 1990 Oct;162(2):165-71. PubMed PMID: 2250195.
  14. McDougall CJ, Ngoi SS, Goldman IS, Godwin T, Felix J, DeCosse JJ, et al. Reduced expression of HLA class I and II antigens in colon cancer. Cancer Res. 1990 Dec 15;50(24):8023-7. PubMed PMID: 2123744.
  15. Barkley D, Allard S, Feldmann M, Maini RN. Increased expression of HLA-DQ antigens by interstitial cells and endothelium in the synovial membrane of rheumatoid arthritis patients compared with reactive arthritis patients. Arthritis Rheum. 1989 Aug;32(8):955-63. PubMed PMID: 2765009.
  16. Farthing PM, Cruchley AT. Expression of MHC class II antigens (HLA DR, DP and DQ) by keratinocytes in oral lichen planus. J Oral Pathol Med. 1989 May;18(5):305-9. PubMed PMID: 2475620.
  17. Möller P, Mattfeldt T, Gross C, Schlosshauer P, Koch A, Koretz K, et al. Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated invariant chain (Ii) in non-neoplastic mammary epithelium, fibroadenoma, adenoma, and carcinoma of the breast. Am J Pathol. 1989 Jul;135(1):73-83. PubMed PMID: 2549795. (Free PMC Article available)
  18. Taylor PM, Rose ML, Yacoub MH. Expression of MHC antigens in normal human lungs and transplanted lungs with obliterative bronchiolitis. Transplantation. 1989 Sep;48(3):506-10. PubMed PMID: 2675409.
  19. Barker JN, Ophir J, MacDonald DM. Products of class II major histocompatibility complex gene subregions are differentially expressed on keratinocytes in cutaneous diseases. J Am Acad Dermatol. 1988 Oct;19(4):667-72. PubMed PMID: 2460509.
  20. Borthwick GM, Holmes RC, Stirrat GM. Abnormal expression of class II MHC antigens in placentae from patients with pemphigoid gestationis: analysis of class II MHC subregion product expression. Placenta. 1988 Jan-Feb;9(1):81-94. PubMed PMID: 3283723.
  21. Brooks CF, Moore M. Differential MHC class II expression on human peripheral blood monocytes and dendritic cells. Immunology. 1988 Feb;63(2):303-11. PubMed PMID: 3350576. (Free PMC Article available)
  22. Hayashi T, Morimoto C, Burks JS, Kerr C, Hauser SL. Dual-label immunocytochemistry of the active multiple sclerosis lesion: major histocompatibility complex and activation antigens. Ann Neurol. 1988 Oct;24(4):523-31. PubMed PMID: 3266456.
  23. Kelly J, Weir DG, Feighery C. Differential expression of HLA-D gene products in the normal and coeliac small bowel. Tissue Antigens. 1988 Mar;31(3):151-60. PubMed PMID: 3376099.
  24. Oliver AM, Thomson AW, Sewell HF, Abramovich DR. Major histocompatibility complex (MHC) class II antigen (HLA-DR, DQ, and DP) expression in human fetal endocrine organs and gut. Scand J Immunol. 1988 Jun;27(6):731-7. PubMed PMID: 3293192.
  25. Thrane PS, Brandtzaeg P. Differential expression of epithelial MHC class II determinants (HLA-DR, -DP, and -DQ) and increased class I expression in inflamed salivary glands. Adv Exp Med Biol. 1988;237:681-8. PubMed PMID: 3254070.
  26. Vermeer BJ; Mommaas AM; Wijsman MC; Koning F; Claas FH. Ultrastructural localization of HLA-DR and HLA-DQ molecules in Langerhans cells and B cells: an immunoelectronmicroscopic study. Regional Immunology, 1988, 1(2):85-91. 1. Spits H et. al. Hybridoma, 1983, 2(4):423-37.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
0.09% Sodium Azide
IgG purified
Ig Fraction
Human, Porcine

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