NB100-2729 HPV16 + HPV18 E6 Protein antibody

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Mouse anti Virus HPV16 + HPV18 E6 Protein C1P5


Product Description for HPV16 + HPV18 E6 Protein

Mouse anti Virus HPV16 + HPV18 E6 Protein C1P5.
Product is tested for Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.

Properties for HPV16 + HPV18 E6 Protein

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms HPV16 E6, HPV18 E6, Human Papilloma Virus Early protein 6
Reactivity Vi
Applications IP, P, WB
Clonality Monoclonal
Clone C1P5
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Gel-purified HPV-18 E6-beta galactosidase fusion protein.
Add. information Research Areas: Immunology
Application Immunohistochemistry-Paraffin, immunoprecipitation, Western Blot, Immunoprecipitation, Western Blot and Immunohistochemistry-Paraffin Reactive on formalin fixed tissue. Reveals a 16.5 kDa MW polypeptide in cells derived from a human cervical carcinoma., immunoprecipitation , Western Blot , Immunohistochemistry-Paraffin
Background Human Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 1, 6 and 11 usually are associated with benign transformations of the tissues, while e.g. HPV types 16, 18 and 31 seem to be responsible for the development of some carcinoma like cervical carcinoma. The role of HPV in non-melanoic tumours of the skin is under discussion. Protein E6 is a Transcriptional transactivator, binding double stranded DNA. It has transforming activity inactivating, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it for degradation. Clinical relevance: Detection of HPV in cervical smears and biopsies. Uses: Analysis of E6 expression in cell transformation studies.
Concentration 1.2 mg/ml
General Readings This product has been used in:Abdulkarim B et al. Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers. Oncogene 21:2334-46 (2002). PubMed PMID: 11948417
Kobayashi A et al. Lymphoid follicles are generated in high-grade cervical dysplasia and have differing characteristics depending on HIV status. Am J Pathol 160:151-64 (2002). PubMed PMID: 11786409
Banks L et al. Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas. J Gen Virol 68 ( Pt 5):1351-9 (1987). PubMed PMID: 3033140
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer System:
No Preservative
HPV16 and HPV18 E6 (C1P5)

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