discontinued

GTX22788 HSC70 antibody

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50 µl / €440.00

Quick Overview

Mouse anti Human, Mouse HSC70 13D3

GTX22788

Product Description for HSC70

Mouse anti Human, Mouse HSC70 13D3.
Presentation: Ascites
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot.

Properties for HSC70

Product Category Primary Antibodies
Quantity 50 µl
Synonyms HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, Heat Shock 70kDa Protein 8, Heat Shock Cognate 71 kDa protein, LAP1, MGC131511, MGC29929, NIP71
Presentation Ascites
Reactivity Hu, Ms
Applications C, IP, WB
Clonality Monoclonal
Clone 13D3
Host Mouse
Isotype IgM
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Mouse spermatogenic cell protein.
Application IHC-Fr, IP, WB
Background The HSP 70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP 70 family members include: HSP 70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP 72, a 72 kDa protein that is induced exclusively under stress conditions; Hsc 70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP 78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or Hsc 75, a 75 kDa protein that is found within the mitochondria. Hsc 70 (also known as Hsc 71, Hsc 73, Hsc 73, p72, prp 73) is expressed constitutively and is slightly heat-inducible. Hsc 70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton, which may facilitate cytoskeletal rearrangements. Hsc 70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
Format
Purification:
Ascites
Buffer System:
PBS with 0.05% sodium azide
Purity:
Ascites
State:
Liquid
Ascites
Specificity
Specificity:
Cross-reacts with Human and Mouse. Not yet tested in other species.

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