discontinued

AM10177SU-N HTLV-1 Tax Protein antibody

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0.2 ml / €400.00

Quick Overview

Mouse anti HTLV-1 Tax Protein 1A3

AM10177SU-N

Product Description for HTLV-1 Tax Protein

Mouse anti HTLV-1 Tax Protein 1A3.
Presentation: Ascites
Product is tested for Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for HTLV-1 Tax Protein

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Ascites
Applications C, E, WB
Clonality Monoclonal
Clone 1A3
Host Mouse
Isotype IgG2a
Molecular weight 40 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P14079
Immunogen:
HTLV-1 Tax Protein
GeneID:
1491938
Application

ELISA.
Western Blot: 1/50-1/500. 
Immunohistochemistry: 1/50-1/800.

Background HTLV-1 causes two distinct human diseases, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma (ATL). The glycoproteins encoded by the env gene of HTLV-1 are essential for interaction with an unidentified receptor on the surface of target cells and play a crucial role in the infection process. Encoded by HTLV-1 Tax is a phospho-oncoprotein that functions as a transcriptional activator. Tax has the ability to modulate the expression and function of many cellular genes and has been crucial to understanding the HTLV-1-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including the CREB/ATF and NFkB pathways. In addition, Tax deregulates the expression of downstream genes, which mediate cell cycle control.
General Readings
  1. Wencker M, Sausse C, Derse D, Gazzolo L, Duc Dodon M. Human T-cell leukemia virus type 1 Tax protein down-regulates pre-T-cell receptor alpha gene transcription in human immature thymocytes. J Virol. 2007 Jan;81(1):301-8. Epub 2006 Oct 18. PubMed PMID: 17050604. (Free PMC Article available, 6 images available)
  2.  Wada, K., et al. 2009. Ro52-mediated monoubiquitination of IKKβ downregulates NFκB signalling. J. Biochem. 146: 821-832.
Storage

Prior to reconstitution store at -20°C.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Preservatives:
None
State:
Lyophilized powder
Ascites
Reconstitution:
Restore in distilled water.
Specificity
Specificity:
This monoclonal antibody reacts with HTLV-1 Tax protein from transiently transfected cells.
Gene ID 1491938

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