discontinued

NB600-1376 HTLV I gp46 (65/6C2.2.34) antibody

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0.1 mg / €390.00

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Mouse anti Human HTLV I gp46 (65/6C2.2.34) 65/6C2.2.34

NB600-1376

Product Description for HTLV I gp46 (65/6C2.2.34)

Mouse anti Human HTLV I gp46 (65/6C2.2.34) 65/6C2.2.34.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for HTLV I gp46 (65/6C2.2.34)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms anti-Glycoprotein 46 antibody, anti-SU antibody, anti-Surface protein antibody
Presentation Aff - Purified
Reactivity Hu
Applications E, ICC/IF, IP, WB
Clonality Monoclonal
Clone 65/6C2.2.34
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
The epitope is located between amino acids 210-306 of the viral env gene. Cross- reactivity with the surface protein of HTLV-II (MoT) has been observed.
Application ELISA, immunofluorescence, immunoprecipitation, Western Blot,

Anti-HTLV-I gp46 (clone 65/6C2.2.34) exhibits reactivity with viral lysates using solidphase enzyme immunoassay and immunoblotting.

It also reacts with HTLV-I infected cell lines using indirect immunofluorescence.

The antibody immunoprecipitates gp46 surface protein from radiolabeled cell lysates, as well as viral precursor protein., ELISA , immunofluorescence , immunoprecipitation , Western Blot

Background

HTLV I gp46 surface protein is processed from its precursor gp62. It attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.

The antibody is used to detect HTLV-I surface protein and its precursor in lysates prepared from virons or infected cells. Using immunoblotting and/or radioimmunoprecipitation analysis, the biosynthesis and metabolism of viral surface protein may be studied.

Concentration 1 mg/ml
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
No Preservative
Purity:
Affinity purified
State:
Aff - Purified
Specificity
Specificity:
This murine monoclonal reacts with Human T-Lymphotropic Virus Type I (HTLV-I) surface protein, gp46.
Species:
Human

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