AP01748PU-N I Kappa K alpha/beta (IKKa/IKKb) pSer176/177 antibody

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Rabbit anti Human, Mouse I Kappa K alpha/beta (IKKa/IKKb)


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  • AP01748PU-N

Product Description for I Kappa K alpha/beta (IKKa/IKKb)

Rabbit anti Human, Mouse I Kappa K alpha/beta (IKKa/IKKb).
Properties: pSer176/177
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for I Kappa K alpha/beta (IKKa/IKKb)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms I Kappa K alpha, I kappa B kinase 2, I kappa B kinase beta, IKK2, IKKB, IKKa, IkBKB, IkappaK alpha, Inhibitor of kappa light chain gene enhancer in B cells, Inhibitor of kappa light polypeptide gene enhancer in B cells, Inhibitor of nuclear factor kappa B kinase beta subunit, NFKBIKB, Nuclear factor NF kappa B inhibitor kinase beta, kinase beta
Presentation Aff - Purified
Reactivity Hu, Ms
Applications P, WB
Clonality Polyclonal
Host Rabbit
Molecular weight ~ 85 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Property pSer176/177
Application Immunohistochemistry on paraffin sections: 1/50-1/200.
Western blot: 1/500-1/1000.
Background The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα) interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, designated IKKα, IKKβ and IKKγ (also designated NEMO); each appears to make essential contributions to IκB phosphorylation. NFκB inducing kinase (NIK) phosphorylates IKKα at Serine 176.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Affinity Chromatography using epitope-specific immunogen.
Buffer System:
Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Aff - Purified
Species Reactivity
Species reactivity (expected):
Species reactivity (tested):
This antibody detects endogenous levels of IKK-alpha pSer176/IKK-beta pSer177 protein.

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