NB500-201 IAP4 / BIRC5 antibody

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0.1 ml / €330.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Canine, Feline, Human, Mouse, Rat IAP4 / BIRC5

NB500-201

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  • NB500-201
  • NB500-201

Product Description for IAP4 / BIRC5

Rabbit anti Canine, Feline, Human, Mouse, Rat IAP4 / BIRC5.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.

Properties for IAP4 / BIRC5

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
Presentation Purified
Reactivity Can, Fe, Hu, Ms, Rt
Applications ICC/IF, IP, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
O15392
Immunogen:
Full-length recombinant human survivin.
GeneID:
332
Add. information Research Areas: Stem Cell Markers, Cancer, Neuroscience
Application Immunocytochemistry, immunofluorescence, Immunohistochemistry-Paraffin, immunoprecipitation, Western Blot, By Western blot, this antibody recognizes a band at ~16.5 kDa representing survivin. Immunohistochemistry with cytoplasmic and nuclear detection of survivin can be achieved using formalin-fixed paraffin-embedded tissue sections with prior antigen retrieval (pressure cooking)., immunofluorescence , immunoprecipitation , Western Blot 1 ug/ml, Immunocytochemistry , Immunohistochemistry-Paraffin 0.5 ug/ml
Background Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminal RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.
Concentration 0.97 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Lu H, Cao X, Chen Q, Chen L, Chen L, Gan M. The Expression and Role of MEKK3 in Renal Clear Cell Carcinoma. Anat Rec (Hoboken). 2014 Nov 12. doi: 10.1002/ar.23093. PubMed PMID: 25388155.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
0.05% Sodium Azide
Purity:
Affinity purified
State:
Purified
Specificity
Specificity:
This is specific for survivin.
Species:
Canine, Feline, Human, Mouse, Rat
Gene ID 332

Accessory Products

Proteins and/or Positive Controls

Proteins for IAP4 / BIRC5 (11 products)

Catalog No. Species Pres. Purity   Source  

IAP4 / BIRC5 (transcript variant 1)

IAP4 / BIRC5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

IAP4 / BIRC5 (full length)

IAP4 / BIRC5 Human Purified > 90 % > 90% by SDS PAGE E. coli
0.5 mg / €800.00
  Acris Antibodies GmbH

IAP4 / BIRC5 (full length)

IAP4 / BIRC5 Human Purified > 90 % > 90% by SDS PAGE E. coli
0.1 mg / €310.00
  Acris Antibodies GmbH

IAP4 / BIRC5 control peptide

Western blot analysis of survivin in MOLT4 cell lysate in the absence (A) or presence (B) of blocking peptide (GTX27865) with Survivin antibody at 1 μg/mL. n/a
50 µg / €240.00
  GeneTex Inc.

IAP4 / BIRC5 control peptide

IAP4 / BIRC5 Human n/a
50 µg / €240.00
  GeneTex Inc.

IAP4 / BIRC5

IAP4 / BIRC5 E. coli Aff - Purified Purified by nickel NTA affinity chromatography
50 µg / €740.00
  GeneTex Inc.

IAP4 / BIRC5

IAP4 / BIRC5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

IAP4 / BIRC5

IAP4 / BIRC5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

IAP4 / BIRC5

IAP4 / BIRC5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

IAP4 / BIRC5

IAP4 / BIRC5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

IAP4 / BIRC5

SDS-Page: Survivin Protein [NBC1-18508] - Survivin, 33 kDa (294 aa) , confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE Protein
0.1 mg / €380.00
  Novus Biologicals Inc.

Positive controls for IAP4 / BIRC5 (4 products)

Catalog No. Species Pres. Purity   Source  

BIRC5 overexpression lysate

BIRC5 overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.

BIRC5 overexpression lysate

BIRC5 overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.

IAP4 / BIRC5 Lysate(Denatured)

IAP4 / BIRC5 Lysate(Denatured)
0.1 ml / €270.00
  Abnova Taiwan Corp.

Survivin Lysate

Western Blot: Survivin Lysate [NBL1-07987] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for BIRC5 Protein
0.1 mg / €400.00
  Novus Biologicals Inc.
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