Product Description for IAP4 / BIRC5
Rabbit anti Canine, Feline, Human, Mouse, Rat IAP4 / BIRC5.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.
Properties for IAP4 / BIRC5
| Product Category | Primary Antibodies |
|---|---|
| Target Category | |
| Quantity | 0.1 ml |
| Synonyms | API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin |
| Presentation | Purified |
| Reactivity | Can, Fe, Hu, Ms, Rt |
| Applications | ICC/IF, IP, P, WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Add. information | Research Areas: Stem Cell Markers, Cancer, Neuroscience |
| Application | Immunocytochemistry, immunofluorescence, Immunohistochemistry-Paraffin, immunoprecipitation, Western Blot, By Western blot, this antibody recognizes a band at ~16.5 kDa representing survivin. Immunohistochemistry with cytoplasmic and nuclear detection of survivin can be achieved using formalin-fixed paraffin-embedded tissue sections with prior antigen retrieval (pressure cooking)., immunofluorescence , immunoprecipitation , Western Blot 1 ug/ml, Immunocytochemistry , Immunohistochemistry-Paraffin 0.5 ug/ml |
| Background | Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminal RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. |
| Concentration | 0.97 mg/ml |
| Product Citations |
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| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Format |
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| Specificity |
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| Gene ID | 332 |
Accessory Products
Proteins and/or Positive Controls
Proteins for IAP4 / BIRC5 (8 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| TP305935 |
IAP4 / BIRC5 (transcript variant 1) |
||||||
|
Human |
> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
|
|||
| OriGene Technologies, Inc. | |||||||
| AR03007PU-L |
IAP4 / BIRC5 (full length) |
||||||
|
Human | Purified | > 90 % > 90% by SDS PAGE | E. coli |
0.5 mg /
€800.00
|
||
| Acris Antibodies GmbH | |||||||
| AR03007PU-N |
IAP4 / BIRC5 (full length) |
||||||
|
|
Human | Purified | > 90 % > 90% by SDS PAGE | E. coli |
0.1 mg /
€310.00
|
||
| Acris Antibodies GmbH | |||||||
| H00000332-P01-10 |
IAP4 / BIRC5 |
||||||
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| H00000332-P01-25 |
IAP4 / BIRC5 |
||||||
|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| H00000332-Q01-10 |
IAP4 / BIRC5 |
||||||
|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| H00000332-Q01-25 |
IAP4 / BIRC5 |
||||||
|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| NBC1-18508 |
IAP4 / BIRC5 |
||||||
![SDS-Page: Survivin Protein [NBC1-18508] - Survivin, 33 kDa (294 aa) , confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/Survivin%20Protein-SDS-Page-NBC1-18508-img0001.jpg)
|
Protein | ||||||
| Novus Biologicals Inc. | |||||||
Positive controls for IAP4 / BIRC5 (4 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| LY423314 |
BIRC5 overexpression lysate |
||||||
|
0.1 mg /
€280.00
|
||||||
| OriGene Technologies, Inc. | |||||||
| LY425312 |
BIRC5 overexpression lysate |
||||||
|
0.1 mg /
€280.00
|
||||||
| OriGene Technologies, Inc. | |||||||
| H00000332-T01 |
IAP4 / BIRC5 Lysate(Denatured) |
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|
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| Abnova Taiwan Corp. | |||||||
| NBL1-07987 |
Survivin Lysate |
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![Western Blot: Survivin Lysate [NBL1-07987] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for BIRC5](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/Survivin%20Lysate-Western%20Blot-NBL1-07987-img0001.jpg) |
Protein | ||||||
| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for IAP4 / BIRC5 (9 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | AP | Rb | E, WB | |||
| Acris Antibodies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | Biotin | Rb | E, WB | |||
| Acris Antibodies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | Rb | E, ICC/IF, WB | |||
| Acris Antibodies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | Rb | E, P, WB | |||
| Acris Antibodies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | Rb | E, F, ICC/IF | |||
| Acris Antibodies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
||||||
|
|
Donkey | PE | Rb | F | |||
| Acris Antibodies GmbH | |||||||
| R1458C2 |
Rabbit IgG (H+L chain, adsorbed) antibody |
||||||
|
|
Goat | Cy2 | |||||
| Acris Antibodies GmbH | |||||||
| R1458C3 |
Rabbit IgG (H+L chain, adsorbed) antibody |
||||||
|
|
Goat | Cy3 | |||||
| Acris Antibodies GmbH | |||||||
| R1458C5 |
Rabbit IgG (H+L chain, adsorbed) antibody |
||||||
|
Goat | Cy5 | |||||
| Acris Antibodies GmbH | |||||||
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