AP08569PU-N IFT74 (588-600) antibody

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50 µg / €380.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Goat anti Human, Monkey IFT74

AP08569PU-N

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  • AP08569PU-N

Product Description for IFT74

Goat anti Human, Monkey IFT74.
Properties: (588-600)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for IFT74

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms CCDC2, CMG-1, CMG1, Capillary morphogenesis protein 1, Coiled-coil domain-containing protein 2, Intraflagellar transport protein 74 homolog
Presentation Aff - Purified
Reactivity Hu, Mky
Applications E, P, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q96LB3
Immunogen:
Synthetic peptide from the C-terminus of Human IFT74
AA Sequence:
C-KTIVDALHSTSGN
GeneID:
80173
Remarks:
Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset (100%); Gibbon (92%); Rabbit (85%)
Property 588-600
Application ELISA: 1/16000.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot.
Background Capillary morphogenesis protein 1 (CMG1) is a 600 amino acid protein and has a calculated molecular mass of 65 kD. CMG1 contains a coiled-coil domain (which shares 24% identity with myosin heavy chain sequences from various species) and several putative phosphorylation sites. Bell et al. (2001) determined that CMG1 was 1 of several transcripts upregulated by umbilical vein endothelial cells during capillary morphogenesis in 3-dimensional collagen matrices. RT-PCR detected highest expression in adult and fetal kidney and lower expression in adult heart, placenta, lung, liver, and pancreas, and in fetal heart, lung, and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus, and spleen. Transfection into epithelial tumor cells revealed targeting of fluorescent-tagged CMG1 to an intracellular vesicular compartment.
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chi A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, Hutton ML, Rogaeva E, St George-Hyslop P, Rothstein JD, Hardiman O, Grafman J, Single. BMC neurology. 2006 6:44. [PubMed:17166276] [PMC:PMC1764752]
  2. Boldt K, Mans DA, Won J, van Reeuwijk J, Vogt A, Kinkl N, et al. Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. J Clin Invest. 2011 Jun;121(6):2169-80. doi: 10.1172/JCI45627. Epub 2011 May 23. PubMed PMID: 21606596. (Free PMC Article available, 5 images available)
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography
Buffer System:
Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Gorilla, Orangutan, Monkey, Marmoset, Gibbon, Rabbit
Specificity
Specificity:
Recognizes IFT74/CMG1 at aa 588-600.
Gene ID 80173

Accessory Products

Proteins and/or Positive Controls

Proteins for IFT74 (2 products)

Catalog No. Species Pres. Purity   Source  

IFT74

IFT74 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

IFT74

IFT74 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.
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