AM06460SU-N IHOG antibody

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0.1 ml / €400.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti IHOG 3G8

Product Description for IHOG

Mouse anti IHOG 3G8.
Presentation: Ascites
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for IHOG

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms CG9211, CT26314, Dmel\CG9211, Ihog, ihog
Presentation Ascites
Applications E, WB
Clonality Monoclonal
Clone 3G8
Host Mouse
Isotype IgG1
Molecular weight 98 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
Purified recombinant fragment of human IHOG expressed in E. Coli.
Application Western Blot: 1/500 - 1/2000.
ELISA: 1/10000.
Background The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
General Readings
  1. Cell. 2006 Apr 21;125(2):343-57.
  2. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17208-13.

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Ascitic fluid containing 0.03% sodium azide.
Species Reactivity
Species reactivity (tested):
Drosophila melanogaster
This antibody reacts to IHOG.
Gene ID 33972

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