NB120-8109 IL-1 Receptor AcP antibody

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Rabbit anti Human IL-1 Receptor AcP


Product Description for IL-1 Receptor AcP

Rabbit anti Human IL-1 Receptor AcP.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for IL-1 Receptor AcP

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Peptide corresponding to amino acids 549 to 569of human IL-1RAcP, which differs from the sequence ofmouse origin by three amino acids (1).
Background The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associatedkinase (IRAK), which mediates activation of NF-kBinducing kinae (NIK) and of NF-kB, recruits to the IL-1R complex through IL-1RAcP. IL-1 activation of stress activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
General Readings General / background references:Hofmeister R et al. Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein. J Biol Chem 272:27730-6 (1997). PubMed PMID: 9346915
Wesche H et al. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem 272:7727-31 (1997). PubMed PMID: 9065432
Huang J et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A 94:12829-32 (1997). PubMed PMID: 9371760
Greenfeder SA et al. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J Biol Chem 270:13757-65 (1995). PubMed PMID: 7775431
Immunogen affinity purified
Buffer System:
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human. Not yet tested in other species.

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