NB100-78211 IL-17, IL-17A antibody

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Rat anti Mouse IL-17, IL-17A TC11-18H10.1


Product Description for IL-17, IL-17A

Rat anti Mouse IL-17, IL-17A TC11-18H10.1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Elispot, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Flow Cytometry.

Properties for IL-17, IL-17A

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms CTLA-8
Presentation Aff - Purified
Reactivity Ms
Applications E, Elispot, F, ICC/IF, WB
Clonality Monoclonal
Clone TC11-18H10.1
Host Rat
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

E. coli-expressed, recombinant mouse IL-17A
Application ELISA, ELISPOT Capture, Immunocytochemistry, flow cytometry / FACS analysis, Western Blot
Background IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. Recent study has shown that IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts; activation of NF- kappaB and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. The TC11-18H10.1 antibody can neutralize IL-17A activity.
General Readings
  1. Fitzgerald, K., et al., Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego. 2. Numasaki, M., et al., 2002. Blood 101:2620. 3. Fossiez, F., et al., 1996. J. Exp. Med. 183:2593.
Storage Store at 4C. Do not freeze.
Immunogen affinity purified
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Immunogen affinity purified
Aff - Purified

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