discontinued

NB100-56547 IL-17B/E R antibody

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0.1 mg / €380.00

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Mouse anti Human IL-17B/E R 97C691

NB100-56547

Product Description for IL-17B/E R

Mouse anti Human IL-17B/E R 97C691.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for IL-17B/E R

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Monoclonal
Clone 97C691
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
A recombinant protein of human IL-17BR was used as immunogen.
Background Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E (2). IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis (3), multiple sclerosis (4), and promotion of tumor growth (5). IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al (6) and Lee, et al. (2) and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain (2).
Format
Purification:
Affinity Purified
Buffer System:
PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.
Purity:
Affinity Purified
State:
Aff - Purified
Specificity
Species:
Human Not yet tested in other species.

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