NB100-55737 IL-27 antibody

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Rabbit anti Human, Monkey IL-27


Product Description for IL-27

Rabbit anti Human, Monkey IL-27.
Presentation: Serum
Product is tested for Enzyme Immunoassay.

Properties for IL-27

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Reactivity Hu, Mky
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Amino acids 141-155 (RLDLRDLQRHLRFQV) of human IL-27 protein was used as the immunogen.
Background IL-27 is a 243 aa, novel heterodimeric cytokine belonging to the IL-6/IL-12 family and produced by activated antigen-presenting cells. It is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) and p28. Recent reports suggest that IL-27 is a potent inhibitor of HIV-1 replication in PBMCs, CD4 (+) T cells and macrophages. It has antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities. It is also responsible for early regulation of Th1 adaptive immune response. It strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4 (+) T cells and drives rapid clonal expansion of naive but not memory CD4 (+) T cells through the cytokine receptor WSX-1/TCCR.
Whole antisera
Buffer System:
Rabbit sera with 50% glycerol and 0.025% sodium azide
Whole antisera
Chimpanzee, Dog, Human Not yet tested in other species.

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