NBP1-28172 IL2 Receptor beta (5H4) antibody

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Rat anti Mouse IL2 Receptor beta (5H4) 5H4


Product Description for IL2 Receptor beta (5H4)

Rat anti Mouse IL2 Receptor beta (5H4) 5H4.
Presentation: Purified
Product is tested for Immunoprecipitation, Flow Cytometry.

Properties for IL2 Receptor beta (5H4)

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms anti-CD122 antibody, anti-CD122 antigen antibody, anti-IL2 receptor antibody, anti-IL2RB antibody, anti-Interleukin 2 Receptor beta antibody, anti-P70 75 antibody, anti-p75 antibody
Presentation Purified
Reactivity Ms
Applications F, IP
Clonality Monoclonal
Clone 5H4
Host Rat
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rat myeloma YB2/0 transfected with truncated mouse IL-2RB cDNA (1)
Isotype control SM15P, SM15PX
Add. information Inquire about low endotoxin, azide-free CD122 antibody.
Application flow cytometry / FACS analysis, immunoprecipitation, Flow cytometry / FACS and Immunoprecipitation, flow cytometry / FACS analysis , immunoprecipitation
Background The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the alpha chain which binds IL-2 with low affinity; (ii) the beta chain that binds IL-2 with high affinity; and (ii) the common gamma chain (gamma C) that does not bind IL-2. (2) The high affinity receptor complex is an alpha/beta/gamma heterotrimer with a Kd of 1.3 x 10^-11 M. (2) In mouse spleen, CD122 is expresed on approx. 30% of CD8+ cells and all NK cells, but <1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. (4) Cytoplasmic regions of the IL-2R beta chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. (1, 4) The monoclonal antibody 5H4 does not block IL-2 binding. (1)
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
No Preservative
IgG purified
beta chain (Mr 90-100 kDa) of the IL-2 receptor.

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