NB100-75592 IL21 antibody

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Chicken anti Human, Mouse, Rat IL21


Product Description for IL21

Chicken anti Human, Mouse, Rat IL21.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for IL21

Product Category Primary Antibodies
Quantity 0.05 mg
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Chicken
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

The immunogen for this antibody was a sequence from 18a.a. to 146a.a. from IL21(a 146a.a. long protein)
Application ELISA, Western Blot
Background A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. IL21 has been found to be a powerful growth factor for naive B cells. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.
General Readings 1. Caven,T.H., Shelburne,A., Sato,J., Chan-Li,Y., Becker,S. and Conrad,D.H.
IL-21 dependent IgE production in human and mouse in vitro culture systems is cell density and cell division dependent and is augmented by IL-10
2. Kim,H.P., Korn,L.L., Gamero,A.M. and Leonard,W.J., et al.
Calcium-dependent activation of interleukin-21 gene expression in T cells
3. Vollmer,T.L., Liu,R., Price,M., Rhodes,S., La Cava,A. and Shi,F.D., et al.
Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen
4. Mehta,D.S., Wurster,A.L., Weinmann,A.S. and Grusby,M.J., et al.
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
5. Pelletier,M., Bouchard,A. and Girard,D., et al.
In vivo and in vitro roles of IL-21 in inflammation
6. , Pandian R.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
Phosphate-Buffered Saline.
Immunogen affinity purified
Aff - Purified
This antibody is reactive against Human, mouse, rat.

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