discontinued

bs-4976R Influenza A H1N1 (Nucleoprotein) antibody

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Search for all "Influenza A H1N1"

0.1 ml / €240.00

Quick Overview

Rabbit anti Virus Influenza A H1N1

bs-4976R

Product Description for Influenza A H1N1

Rabbit anti Virus Influenza A H1N1.
Properties: (Nucleoprotein)
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Influenza A H1N1

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Purified
Reactivity Vi
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Bioss, Inc.

Datasheet Extract

Immunogen
Immunogen:
KLH conjugated synthetic peptide derived from Influenza A virus H1N1 Nucleoprotein.
Property Nucleoprotein
Background Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Product Citations
Originator or purchased from resellers:
  1. Chen, Hongjun, et al. "All-in-one bacmids: An efficient reverse genetics strategy for influenza A virus vaccines." Journal of Virology (2014): JVI-01468.
Storage Store at -20°C for 12 months.
Format
Purification:
Purified by Protein A and peptide affinity chromatography.
Buffer System:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
State:
Purified

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