discontinued

GTX45733 Insulin degrading enzyme / IDE [9B12.225] antibody

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0.1 ml / €440.00

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Mouse anti Hamster, Human, Monkey, Rat Insulin degrading enzyme / IDE [9B12.225] 9B12.225

GTX45733

Product Description for Insulin degrading enzyme / IDE [9B12.225]

Mouse anti Hamster, Human, Monkey, Rat Insulin degrading enzyme / IDE [9B12.225] 9B12.225.
Presentation: Ascites
Product is tested for Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.

Properties for Insulin degrading enzyme / IDE [9B12.225]

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Ascites
Reactivity Hst, Hu, Mky, Rt
Applications IP, P, WB
Clonality Monoclonal
Clone 9B12.225
Host Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
purified human erythrocyte IDE.
Application IHC-P, IP, WB
Background Insulin-degrading enzyme (IDE) is a metalloprotease with a molecular weight of 110 kDa that is expressed in many tissue types, with high concentrations noted in brain. IDE has a preferential affinity for insulin such that the presence of insulin will inhibit IDE-mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A-beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A-beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma-secretase cleaved APP that may function in nuclear signaling.
Concentration 1 mg/ml
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Ascites
Buffer System:
Preservative: None; Constituents: Ascites
Purity:
Ascites
State:
Liquid
Ascites
Specificity
Specificity:
Reacts with Human, Rat, Hamster and Monkey. Does not react with Mouse.Not yet tested in other species.

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