BM519 Integrin alpha V / beta 5 antibody

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Mouse anti Human Integrin alpha V / beta 5 P1F6


Product Description for Integrin alpha V / beta 5

Mouse anti Human Integrin alpha V / beta 5 P1F6.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Functional assay, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Flow Cytometry.

Properties for Integrin alpha V / beta 5

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Integrin beta 5, Vitronectin receptor
Presentation Purified
Reactivity Hu
Applications C, E, F, FN, ICC/IF, IP
Clonality Monoclonal
Clone P1F6
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Human UCLA P3 cells (lung carcinoma).
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application ELISA.
Flow Cytometry.
Immunohistochemistry on Frozen sections: For use on Human carcinomas, normal epithelium and keratinocytes using Acetone or Paraformaldehyde fixed tissue sections.
Background Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Concentration 1.0 mg/ml
General Readings
  1. Aplin JD, Spanswick C, Behzad F, Kimber SJ, Vićovac L. Integrins beta 5, beta 3 and alpha v are apically distributed in endometrial epithelium. Mol Hum Reprod. 1996 Jul;2(7):527-34. PubMed PMID: 9239663.
  2. Wayner EA, Orlando RA, Cheresh DA. Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface. J Cell Biol. 1991 May;113(4):919-29. PubMed PMID: 1709170. (Free PMC Article available)
  3. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, et al. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994 Mar 4;269(9):6940-8. PubMed PMID: 8120056.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinioty Chromatography on Protein A
Buffer System:
PBS containing 0.09% Sodium Azide as preservative
Liquid purified IgG fraction
This antibody reacts to Integrin alpha V beta 5. When used at > 1/1000, this antibody inhibits the attachment of HT29 cells to vitronectin. It also inhibits the attachment of carcinoma and melanoma cells to vitronectin.
Human, Chicken.

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