NB100-74446 IP3 Receptor Type I antibody

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Rabbit anti Mouse, Rat IP3 Receptor Type I


Product Description for IP3 Receptor Type I

Rabbit anti Mouse, Rat IP3 Receptor Type I.
Presentation: Serum
Product is tested for Western blot / Immunoblot.

Properties for IP3 Receptor Type I

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Reactivity Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide corresponding to residues N(a.a. 1829) K K K D D E V D R D A P S R K K A K E(a.a. 1848) of human IP3 Receptor Type I.
Application Western Blot Assay dependent
Background Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations.

Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. Type-I IP3R has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II protein is found predominantly in the brain. Isoform III expression has been shown to occur in pancreatic islets, kidney and the gastrointestinal tract.
Storage Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Whole antisera
Whole antisera
This antibody is reactive against Rat and Mouse.

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