AM33256SU-N IPO-38 Proliferation marker antibody

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0.5 ml / €290.00
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Mouse anti Human, Mouse, Rat IPO-38 Proliferation marker SPM515

AM33256SU-N

Product Description for IPO-38 Proliferation marker

Mouse anti Human, Mouse, Rat IPO-38 Proliferation marker SPM515.
Presentation: Supernatant
Product is tested for Immunocytochemistry/Immunofluorescence, Frozen Sections, Paraffin Sections.

Properties for IPO-38 Proliferation marker

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms IPO38
Presentation Supernatant
Reactivity Hu, Ms, Rt
Applications C, ICC/IF, P
Clonality Monoclonal
Clone SPM515
Host Mouse
Isotype IgM
Molecular weight 14-16kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Spleen cells of a patient with hairy cell leukemia.
Application Immunofluorescence: 1/50-1/100.  
Immunohistochemistry on Frozen and Formalin-Fixed, Paraffin Sections:
1/100-1/200 for 30 min at RT.
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Positive Control: Raji and PHA-stimulated  (>12 hours) Human or Mouse lymphocytes. Breast and colorectal carcinomas.
Background IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin's disease and non-Hodgkin's lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes.
General Readings
  1. Sidorenko SP, Vetrova EP, Iurchenko OV, Shlapatskaia LN, Berdova AG, Elenskaia AM, et al. [Monoclonal antibodies of the IPO series in studying and diagnosing malignant lymphoproliferative diseases]. Gematol Transfuziol. 1990 Apr;35(4):19-22. PubMed PMID: 2373343.
  2. Mikhalap SV et al. Monoclonal antibody IPO-38 recognizes a novel nuclear antigen of proliferating cells. In Kishimoto T et al eds. Leukocyte Typing VI, p609-610, Garland Publishing, New York, 1997.
  3. Mathews MB, Bernstein RM, Franza BR, Garrels JI. Identity of the proliferating cell nuclear antigen and cyclin. Nature. 1984 May 24-30;309(5966):374-6. PubMed PMID: 6145097.
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Preservatives:
0.05% Sodium Azide
State:
Liquid Bioreactor Concentrate
Supernatant
Specificity
Specificity:
Recognizes a protein of 14-16kDa, which is a novel nuclear antigen of proliferating cells. IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin’s disease and non-Hodgkin’s lymphomas, different forms of leukemias,  breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes.
IPO-38 can be a  useful marker of cell proliferation during monitoring  of tumor progression.
Cellular Localization: Nucleus.
Species:
Human, Mouse, Rat.

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