SP6298P IRAK (aa 700-712) antibody

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50 µg / €250.00

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Rabbit anti Human, Mouse, Rat IRAK


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  • SP6298P

Product Description for IRAK

Rabbit anti Human, Mouse, Rat IRAK.
Properties: (aa 700-712)
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for IRAK

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Peptide corresponding to amino acids 700 to 712 of human IRAK
GenBank accession no. P51617.
Peptide available as SP6298CP.
Property aa 700-712
Application Western blot (1.0 µg/ml; a band of 80 kDa will be detected).
Immunoprecipitation (2.0-4.0 µg per sample).
Positive Control: THP-1, HeLa whole cell lysate.
Background Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) was recently identified (1, 2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1, 4).
Concentration 0.2 mg/ml
General Readings
  1. Cao Z. et al. Science; 271,1128 (1996).
  2. Trofimova M. et al. J. Bio. Chem. 271,17609 (1996).
  3. Jianing H. et al. Proc. Natl. Acad. Sci. USA 94, 12829 (1997).
  4. Robinson D. et al. Immunity 7, 571 (1997).
Storage Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
1x PBS containing 0.05 % sodium azide
Liquid purified Ig fraction
Aff - Purified
SP6298P recognises an 80 kD serin/threonine protein kinase designated IRAK. It has no cross response to IRAK2.
Human, Mouse, Rat.

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