TA306553 IRGM / LRG-47 antibody

Rabbit Polyclonal IRGM Antibody

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0.1 mg / €371.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat IRGM / LRG-47


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  • TA306553
  • TA306553

Product Description for IRGM / LRG-47

Rabbit anti Human, Mouse, Rat IRGM / LRG-47.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for IRGM / LRG-47

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms IFI1, IRGM1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LRG47
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Swiss Prot Num:
IRGM antibody was raised against a 14 amino acid peptide near the center of the human IRGM.
Add. information Blocking peptide available: AP30455CP-N
Application ELISA:
Western blot: 1 – 2 μg/ml.
Immunohistochemistry on paraffin sections.
Background Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn’s disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.
General Readings
  1. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004 Apr 12;23(16):2891-906. PubMed PMID: 15077152.
  2. Massey DC, Parkes M. Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. Autophagy. 2007 Nov-Dec;3(6):649-51. Epub 2007 Sep 24. PubMed PMID: 17921695.
  3. Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet. 2008 Jun;40(6):710-2. doi: 10.1038/ng.145. Epub 2008 Apr 27. PubMed PMID: 18438406. (Free PMC Article available)
  4. Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006 Sep 8;313(5792):1438-41. Epub 2006 Aug 3. PubMed PMID: 16888103.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Peptide affinity chromatography
Buffer System:
PBS containing 0.02% sodium azide
Liquid Ig fraction
Aff - Purified
This antibody detects IRGM at center.

Accessory Products

Proteins and/or Positive Controls

Proteins for IRGM / LRG-47 (4 products)

Catalog No. Species Pres. Purity   Source  

IRGM (23-181, His-tag)

IRGM Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

IRGM (23-181, His-tag)

IRGM Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH


IRGM / LRG-47 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.


IRGM / LRG-47 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.
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