discontinued

AP22717PU-N IRS1 (1223-1242) antibody

See related secondary antibodies

Search for all "IRS1"

Quick Overview

Rabbit anti Human, Mouse, Rat IRS1

AP22717PU-N

More Views

  • AP22717PU-N
  • AP22717PU-N

Product Description for IRS1

Rabbit anti Human, Mouse, Rat IRS1.
Properties: (1223-1242)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for IRS1

Product Category Primary Antibodies
Target Category
Quantity 0.25 ml
Synonyms IRS-1, Insulin receptor substrate 1
Presentation Purified
Reactivity Hu, Ms, Rt
Applications P
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P35568
Immunogen:
IRS1 antibody was raised against synthetic peptide corresponding to aa 1223-1242 of human IRS-1
GeneID:
3667
Property 1223-1242
Application Immunohistochemistry on Paraffin Sections: 15 µg/ml.
Background Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.
Storage

Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.

Format
Purification:
Immunoaffinity Chromatography
Buffer System:
10 mM PBS, pH 7.4
Preservatives:
Sodium Azide
Stabilizers:
BSA
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
This antibody reacts to Insulin Receptor Substrate-1 (IRS1).
Species:
Human, Mouse, Rat.
Gene ID 3667

Accessory Products

  • LinkedIn