AM31992PU-N Jo-1 autoantigen antibody

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0.1 mg / €650.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human Jo-1 autoantigen 7BH12

AM31992PU-N

Product Description for Jo-1 autoantigen

Mouse anti Human Jo-1 autoantigen 7BH12.
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Jo-1 autoantigen

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu
Applications E
Clonality Monoclonal
Clone 7BH12
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Isotype control AM03096PU-N
Application ELISA
Background

Systemic auto-immune diseases are characterised by the production of antibodies directed to a broad range of self-antigens. Recent evidence indicates that the majority of these
autoantigens undergo structural modifications during apoptotic and necrotic cell death, including proteolysis, hyperphosphorylation, dephosphorylation, nucleolytic cleavage or degradation and transglutaminase crosslinking [1]. In myositis the Jo-1 autoantigen is more frequently targeted by the immune system in contrast to other tRNA synthetases [2].

Concentration 0.5 mg/ml
General Readings
  1. Utz PJ, Anderson P. Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis Rheum. 1998 Jul;41(7):1152-60. PubMed PMID: 9663470.
  2. Rodenburg RJ, Raats JM, Pruijn GJ, van Venrooij WJ. Cell death: a trigger of autoimmunity? Bioessays. 2000 Jul;22(7):627-36. PubMed PMID: 10878575.
Storage Store the antibody undiluted at 2-8°C .
Shelf life: one year from despatch.
Format
Buffer System:
100 mM Tris-HCl, pH 8.0
Preservatives:
0.05% Sodium Azide
Stabilizers:
50% (v/v) Glycerol
State:
Liquid purified Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
Human Jo-1 protein

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