TA328638 KCNMB2 antibody

Rabbit Polyclonal Anti-slobeta2 (KCNMB2)

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0.2 ml / €622.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Rat KCNMB2

TA328638

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  • TA328638

Product Description for KCNMB2

Rabbit anti Human, Rat KCNMB2.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for KCNMB2

Product Category Primary Antibodies
Target Category
Quantity 0.2 ml
Synonyms BK channel subunit beta-2, BKbeta2, Calcium-activated potassium channel subfamily M subunit beta-2, Calcium-activated potassium channel subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2
Presentation Purified
Reactivity Hu, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9Y691
Immunogen:
Peptide (C)RHDEKRNIYQKIRDHDLLD, corresponding to amino acid residues 14-32 of human sloÃ?2.Intracellular, N-terminal part.
GeneID:
10242
Application WB: 1:200-1:2000; IHC: 1:100-1:3000
Background sloÃ?2 is a member the regulatory Ã? subunit family that controls the activity of the large conductance Ca2+-activated K+ channel KCa1.1. This family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region and a distinct tissue distribution. sloÃ?2 expression is relatively broad and includes expression in brain, heart, kidney adrel chromaffin cells and ovary. The KCa1.1 K+ channel can be activated by either an increase in intracellular Ca2+ concentration or by membrane depolarization. The regulatory Ã? subunits increase the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and membrane voltage and they may also change the channel pharmacology. The sloβ2 subunit is unique in that it is able to induce a rapid and complete ictivation of the KCa1.1 channel in a manner that closely resembles the ball-and-chain ictivation of the voltage-dependent K+ (Kv) channels. In other words, the ictivation is dependent on a sequence in the N-termil part of the sloÃ?2 subunit that appears to block the mouth of the ion permeation pathway. The physiological significance of the sloÃ?2 subunit is not clear, but it appears to participate in the ictivation of the KCa1.1 channel in hippocampal CA1 neurons and adrel chromaffin cells.
Format
Purification:
Affinity purified on immobilized antigen.
Buffer System:
Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for KCNMB2 (2 products)

Catalog No. Species Pres. Purity   Source  

KCNMB2

KCNMB2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

KCNMB2

KCNMB2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for KCNMB2 (3 products)

Catalog No. Species Pres. Purity   Source  

KCNMB2 Lysate(Denatured)

KCNMB2 Lysate(Denatured)
  Abnova Taiwan Corp.

KCNMB2 Lysate

Western Blot: KCNMB2 Lysate [NBL1-12191] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for KCNMB2
  Novus Biologicals Inc.

KCNMB2 Lysate

Western Blot: KCNMB2 Lysate [NBL1-12192] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for KCNMB2
  Novus Biologicals Inc.
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