Product Description for KCNMB2
Rabbit anti Human, Rat KCNMB2.
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Properties for KCNMB2
| Product Category | Primary Antibodies |
|---|---|
| Target Category | |
| Quantity | 0.2 ml |
| Synonyms | BK channel subunit beta-2, BKbeta2, Calcium-activated potassium channel subfamily M subunit beta-2, Calcium-activated potassium channel subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2 |
| Presentation | Purified |
| Reactivity | Hu, Rt |
| Applications | WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Shipping to | Europe, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies, Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
| Background | sloÃ?2 is a member the regulatory Ã? subunit family that controls the activity of the large conductance Ca2+-activated K+ channel KCa1.1. This family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region and a distinct tissue distribution. sloÃ?2 expression is relatively broad and includes expression in brain, heart, kidney adrel chromaffin cells and ovary. The KCa1.1 K+ channel can be activated by either an increase in intracellular Ca2+ concentration or by membrane depolarization. The regulatory Ã? subunits increase the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and membrane voltage and they may also change the channel pharmacology. The sloβ2 subunit is unique in that it is able to induce a rapid and complete ictivation of the KCa1.1 channel in a manner that closely resembles the ball-and-chain ictivation of the voltage-dependent K+ (Kv) channels. In other words, the ictivation is dependent on a sequence in the N-termil part of the sloÃ?2 subunit that appears to block the mouth of the ion permeation pathway. The physiological significance of the sloÃ?2 subunit is not clear, but it appears to participate in the ictivation of the KCa1.1 channel in hippocampal CA1 neurons and adrel chromaffin cells. |
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Accessory Products
Proteins and/or Positive Controls
Proteins for KCNMB2 (2 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00010242-P01-10 |
KCNMB2 |
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|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| H00010242-P01-25 |
KCNMB2 |
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|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
Positive controls for KCNMB2 (3 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00010242-T01 |
KCNMB2 Lysate(Denatured) |
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|
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| Abnova Taiwan Corp. | |||||||
| NBL1-12191 |
KCNMB2 Lysate |
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![Western Blot: KCNMB2 Lysate [NBL1-12191] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for KCNMB2](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/KCNMB2%20Lysate-Western%20Blot-NBL1-12191-img0001.jpg) |
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| Novus Biologicals Inc. | |||||||
| NBL1-12192 |
KCNMB2 Lysate |
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![Western Blot: KCNMB2 Lysate [NBL1-12192] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for KCNMB2](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/KCNMB2%20Lysate-Western%20Blot-NBL1-12192-img0001.jpg) |
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| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for KCNMB2 (9 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
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|
|
Goat | AP | Rb | E, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
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|
|
Goat | Biotin | Rb | E, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | Rb | E, ICC/IF, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
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|
Goat | HRP | Rb | E, P, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | Rb | E, F, ICC/IF | |||
| OriGene Technologies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
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|
|
Donkey | PE | Rb | F | |||
| OriGene Technologies GmbH | |||||||
| R1458C2 |
Rabbit IgG (H+L chain, adsorbed) antibody |
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|
|
Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1458C3 |
Rabbit IgG (H+L chain, adsorbed) antibody |
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|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1458C5 |
Rabbit IgG (H+L chain, adsorbed) antibody |
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|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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