TA502059 KEAP1 antibody

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0.1 ml / €379.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human, Mouse KEAP1 OTI1B4

TA502059

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Product Description for KEAP1

Mouse anti Human, Mouse KEAP1 OTI1B4.
Presentation: Purified
Product is tested for Flow Cytometry, Paraffin Sections, Western blot / Immunoblot.

Properties for KEAP1

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Cytosolic inhibitor of Nrf2, INRF2, INrf2, KEAP1, KIAA0132, KLHL19, Kelch-like ECH-associated protein 1, Kelch-like protein 19
Presentation Purified
Reactivity Hu, Ms
Applications F, P, WB
Clonality Monoclonal
Clone OTI1B4
Host Mouse
Isotype IgG1
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q14145
Immunogen:
Full length human recombinnt protein of human KEAP1(NP_987096) produced in HEK293T cell.
GeneID:
9817
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application WB 1:500~2000
IHC 1:150
FLOW 1:100
Background This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two altertively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq].
Product Citations
Originator or purchased from resellers:
  1. Mercado N, Kizawa Y, Ueda K, Xiong Y, Kimura G, Moses A, et al. Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. PLoS One. 2014 Feb 5;9(2):e88168. doi: 10.1371/journal.pone.0088168. eCollection 2014. PubMed PMID: 24505412. (Free PMC Article available, 5 images available)
  2. Michaeloudes C, Mercado N, Clarke C, Bhavsar PK, Adcock IM, Barnes PJ, et al. Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression. J Immunol. 2014 May 15;192(10):4913-20. doi: 10.4049/jimmunol.1301984. Epub 2014 Apr 14. PubMed PMID: 24733848. (Free PMC Article available)
Format
Purification:
Purified from mouse ascites fluids by affinity chromatography
Buffer System:
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for KEAP1 (4 products)

Catalog No. Species Pres. Purity   Source  

KEAP1 (transcript variant 1)

KEAP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

KEAP1 (transcript variant 2)

KEAP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

KEAP1

KEAP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KEAP1

KEAP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Positive controls for KEAP1 (2 products)

Catalog No. Species Pres. Purity   Source  

KEAP1 Lysate

Western Blot: KEAP1 Lysate [NBL1-12225] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for KEAP1
0.1 mg / €400.00
  Novus Biologicals Inc.

KEAP1 Lysate

Western Blot: KEAP1 Lysate [NBL1-12226] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for KEAP1
0.1 mg / €400.00
  Novus Biologicals Inc.
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