discontinued

AP52371PU-N KIR2DS5 (Center) antibody

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0.4 ml / €350.00

Quick Overview

Rabbit anti Human KIR2DS5

Product Description for KIR2DS5

Rabbit anti Human KIR2DS5.
Properties: (Center)
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for KIR2DS5

Product Category Primary Antibodies
Quantity 0.4 ml
Synonyms CD158 antigen-like family member G, CD158G, CD_antigen=CD158g, Flags: Precursor, Killer cell immunoglobulin-like receptor 2DS5, MHC class I NK cell receptor, NKAT-9, NKAT9, Natural killer-associated transcript 9
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q14953
Immunogen:
KLH conjugated synthetic peptide between 160-190 amino acids from the Central region of Human KIR2DS5
Property Center
Add. information Molecular Weight: 33644 Da
Application

ELISA: 1/1000.
Western Blot: 1/100-1/500.

Background Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Concentration lot specific
General Readings Vilches, C., et al. Tissue Antigens 56(5):453-456(2000)
Bottino, C., et al. Eur. J. Immunol. 26(8):1816-1824(1996)
Dohring, C., et al. Immunogenetics 44(3):227-230(1996)
Wagtmann, N., et al. Immunity 2(5):439-449(1995)
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Protein A column, followed by peptide affinity purification
Buffer System:
PBS containing 0.09% (W/V) Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody recognizes Human KIR2DS5 (Center).

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