AP08565PU-N KPNA3 / Importin alpha-3 (509-521) antibody

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50 µg / €380.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Goat anti Bat, Bovine, Canine, Chicken, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat KPNA3 / Importin alpha-3

AP08565PU-N

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  • AP08565PU-N

Product Description for KPNA3 / Importin alpha-3

Goat anti Bat, Bovine, Canine, Chicken, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat KPNA3 / Importin alpha-3.
Properties: (509-521)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for KPNA3 / Importin alpha-3

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms Importin alpha Q2, Karyopherin subunit alpha-3, QIP2, SRP1-gamma
Presentation Aff - Purified
Reactivity Bov, Bt, Can, Chk, Elephant, Eq, Hst, Hu, Mky, Ms, Platypus, Por, Rb, Rt
Applications E, P, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O00505
Immunogen:
Synthetic peptide from the C-terminus of Human KPNA3.
AA Sequence:
C-DPTANLQTKEFNF
GeneID:
3839
Remarks:
Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Lizard (100%); Xenopus (85%)
Property 509-521
Application ELISA.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 0.1 - 0.5 µg/ml.
Background The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Notch1 signaling is mediated by importins alpha 3, 4, and 7. Huenniger K, Krmer A, Soom M, Chang I, Khler M, Depping R, Kehlenbach RH, Kaether C. Cellular and molecular life sciences : CMLS. 2010 67:3187-96. [PubMed:20454918] [PMC:PMC3128743] 2. Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin . Ohara R, Hata K, Yasuhara N, Mehmood R, Yoneda Y, Nakagawa M, Yamashita T. Biochemical and biophysical research communications. 2011 405:697-702. (ICC; Rat) [PubMed:21291862]
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography
Buffer System:
Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Lizard, Xenopus
Specificity
Specificity:
Recognizes Karyopherin Alpha 3 (KPNA3) at aa 509-521.
Gene ID 3839

Accessory Products

Proteins and/or Positive Controls

Proteins for KPNA3 / Importin alpha-3 (3 products)

Catalog No. Species Pres. Purity   Source  

KPNA3 / Importin alpha-3

KPNA3 / Importin alpha-3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

KPNA3 / Importin alpha-3

KPNA3 / Importin alpha-3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

KPNA3 / Importin alpha-3

KPNA3 / Importin alpha-3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for KPNA3 / Importin alpha-3 (1 products)

Catalog No. Species Pres. Purity   Source  

KPNA3 Lysate

Western Blot: KPNA3 Lysate [NBL1-12371] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for KPNA3.
  Novus Biologicals Inc.
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