TA326616 KPNA5 / Importin alpha-6 (N-term) antibody

Rabbit Polyclonal KPNA5 Antibody

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0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse KPNA5 / Importin alpha-6

TA326616

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Product Description for KPNA5 / Importin alpha-6

Rabbit anti Human, Mouse KPNA5 / Importin alpha-6.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for KPNA5 / Importin alpha-6

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Karyopherin subunit alpha-5
Presentation Aff - Purified
Reactivity Hu, Ms
Applications E, ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
O15131
Immunogen:
18 amino acid synthetic peptide near the amino terminus of Human KPNA5 (AP55609CP-N)
GeneID:
3841
Property N-term
Add. information Blocking peptide available: AP55609CP-N
Application Western blot: 1-2 µg/ml. 
Positive Control: EL4 cell lysate. 
Immunofluorescence: Start at 5 µg/ml.
Immunocytochemistry: Start at 5 µg/ml.
Background Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA5 belongs to a subfamily within the KPNA family that also includes KPNA4 and 6 and is thought to be involved in NLS-dependent protein imort into the nucleus.
Concentration 1.0 mg/ml
General Readings
  1. Moroianu J. Molecular mechanisms of nuclear protein transport. Crit Rev Eukaryot Gene Expr. 1997;7(1-2):61-72. PubMed PMID: 9034715.
  2. Gilchrist D, Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem. 2003 Dec 19;278(51):51937-49. Epub 2003 Sep 26. PubMed PMID: 14514698.
  3. Köhler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, et al. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Mol Cell Biol. 1999 Nov;19(11):7782-91. PubMed PMID: 10523667. (Free PMC Article available, 8 images available)
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse.
Specificity
Specificity:
This antibody is predicted not to cross-react with other Importin alpha family members.

Accessory Products

Proteins and/or Positive Controls

Proteins for KPNA5 / Importin alpha-6 (2 products)

Catalog No. Species Pres. Purity   Source  

KPNA5 / Importin alpha-6

KPNA5 / Importin alpha-6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

KPNA5 / Importin alpha-6

KPNA5 / Importin alpha-6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for KPNA5 / Importin alpha-6 (2 products)

Catalog No. Species Pres. Purity   Source  

KPNA5 Lysate

Western Blot: KPNA5 Lysate [NBL1-12373] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for KPNA5
  Novus Biologicals Inc.

KPNA5 overexpression lysate

KPNA5 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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