DM3116 Ku70/Ku80 (XRCC6/XRCC5) antibody

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Mouse anti Human, Monkey, Xenopus Ku70/Ku80 (XRCC6/XRCC5) 162


Product Description for Ku70/Ku80 (XRCC6/XRCC5)

Mouse anti Human, Monkey, Xenopus Ku70/Ku80 (XRCC6/XRCC5) 162.
Presentation: Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Paraffin Sections.

Properties for Ku70/Ku80 (XRCC6/XRCC5)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CTC75, CTC85, CTCBF, DNA-repair protein XRCC5, DNA-repair protein XRCC6, G22P1, Ku-70, Ku70, Ku86, TLAA, XRCC-6, XRCC6
Presentation Purified
Reactivity Hu, Mky, Xen
Applications C, F, ICC/IF, P
Clonality Monoclonal
Clone 162
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Biomeda

Datasheet Extract

Human B-cell nuclei from Plasmacytoid 2p68 Cells.
Isotype control AM03096PU-N
Application Affinity Purification (Order Ab without BSA). Flow Cytometry. Gel Supershift (Order Ab at 1 mg/ml). Immunofluorescence. Immunoprecipitation (Native only): Use Protein A; Ab 2µg/mg protein lysate. Not suitable for Western Blotting. Immunohistology (Formalin/paraffin): Ab 1-2µg/ml for 30 min at RT. Recommended positive control: HeLa Cells, Tonsil. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.2 mg/ml
General Readings
  1. Wang J, et. al. Molecular Biology Reports,1993, 18(1):15-28.
  2. Reeves WH, et. al. Journal of Experimental Medicin
Storage Store the antibody at 4°C. Do not freeze! Shelf life: one year from despatch.
The Ku autoantigen is a heterodimer of 70 kD (p70) and 80 kD (p80) proteins. The p70/p80 dimer is important for function of a 460 kD DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T-antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis. Reacts with Human, Monkey, and Xenopus. Mouse and Rat (Immunoprecipitation only). Does not react with with Bovine and Rabbit. Others not tested. Cellular Localization: nuclear.

Mol. Wt. of Antigen: 70kD and 80kD

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